摘要
白细胞介素-6(interleukin-6,IL-6)为一种多功能的细胞因子,其仅通过与自身受体形成复合体才能进行信号转导从而发挥生物学作用。鉴于IL-6在多种疾病中发挥的重要作用,随着IL-6信号转导系统研究的日益深入,以IL-6及其受体IL-6R、gp130与sIL-6R等为靶点的药物筛选和药物设计将为多种疾病的治疗开辟新的途径。本文以IL-6信号通路为靶点的生物技术药物研究进展作一综述。
Interleukin-6(IL-6)is a multifunctional cytokine that functions by formation of a complex with its receptors and signal transduction.In view of the important role of IL-6 in various diseases,with the deepening of research on IL-6 signal pathway system,drug screening and drug design targeting IL-6 and its receptors IL-6 R,gp130 and sIL-6 R will provide new approaches for treatment of the diseases.This paper reviews the progress in research on biological drugs targeting IL-6 signal pathway.
作者
贾春翠
饶春明
于雷
JIA Chun-cui;RAO Chun-ming;YU Lei(National Institutes for Food and Drug Control,Beijing 100050,China)
出处
《中国生物制品学杂志》
CAS
CSCD
2019年第9期1048-1053,共6页
Chinese Journal of Biologicals
基金
中青年发展研究基金课题(2017B3)
