摘要
白细胞介素-6(IL-6)是一种常见的炎症细胞因子,主要由巨噬细胞、淋巴细胞、神经胶质细胞、视网膜色素上皮细胞、虹膜、睫状体和角膜上皮细胞等生成,是近年来研究最热门的细胞因子之一。IL-6不仅能够诱导分化B淋巴细胞、T淋巴细胞,参与炎症发生,还能促进新生血管形成,其介导的信号转导通路在血管源性眼病、Grave眼病、葡萄膜黑色素瘤等疾病中发挥重要作用,但确切的发病机制有待进一步研究,IL-6及其受体将成为治疗血管源性眼病新的干预靶点。
Interleukin-6(IL-6)is a common inflammatory cytokine,mainly produced by macrophages,lymphocytes,glial cells,retinal pigment epithelial cells,iris,ciliary body and corneal epithelial cells,and is one of the most popular cytokines in recent years.IL-6 could not only induce the differentiation of B lymphocytes,T lymphocytes,be involved in inflammation,but also can promote the new blood vessels formation,that its mediated signal transduction pathways play important roles in vascular ophthalmopathy,Grave′s ophthalmopathy,uveal melanoma and other disease,but the exact pathogeneses need further research.IL-6 and its receptor will become new targets for intervention treatment of vascular origin eye disease.
作者
梁雪娇
杜红艳
LIANG Xuejiao;DU Hongyan(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040,China;Department of Ophthalmology,Inner Mongolia People′s Hospital,Hohhot 010017,China)
出处
《医学综述》
2020年第14期2748-2752,共5页
Medical Recapitulate
