摘要
目的 研究茶多糖对四氧嘧啶小鼠的降血糖作用和机制。方法 ( 1)ICR小鼠预防性给予茶多糖 4周 ,再予四氧嘧啶造模 3天后 ,观察对血糖和肝脏SOD、GSH Px和MDA的影响。 ( 2 )对四氧嘧啶高血糖小鼠予茶多糖 6周 ,观察对血糖和肝葡萄糖激酶的影响。结果 ( 1)预防性给予茶多糖对小鼠造模前后血糖无明显升高。与正常组比较 ,肝脏SOD和GSH Px活性提高 ,MDA含量降低。 ( 2 )茶多糖对四氧嘧啶高血糖小鼠有显著的降血糖作用 ,肝葡萄糖激酶活性增加。结论 茶多糖有显著的降血糖作用 ,其降血糖机制有提高肝脏抗氧化能力 ,增强肝葡萄糖激酶活性。
Objective To investigate the hypoglycemic mechanism of tea polysaccharides in alloxan diabetic mice. Methods (1) After administrated tea polysaccharides for 4 weeks, ICR mice were injected allxon and observed the changes of the level of blood glucose and the activity of SOD, GSH Px and MDA in liver. (2) The diabetic mice induced by alloxan were fed tea polysaccharides for 6 weeks, and observed the changes of the level of blood glucose and the activity of glucokinase in liver. Results (1) The level of blood glucose in the group administrated tea polysaccharides previously didnt increase obviously after injected alloxan, with the activity of SOD and GSH Px increasing and the content of MDA decreasing. (2)The activity of liver glucokinase was higher than those without tea polysaccharides. Conclusions Tea polysaccharides has remarkable hypoglycemic effect on diabetic mice induced by alloxan by mechanisms of enhancing the activity of antioxidant and liver glucokinase.
出处
《浙江预防医学》
2003年第9期10-11,13,共3页
Zhejiang Journal of Preventive Medicine
关键词
茶多糖
降血糖
四氧嘧啶
小鼠
糖尿病
茶叶
Tea polysaccharides Diabetic mellitus Hypoglycemic effect Mouse
