摘要
探讨乙型肝炎慢性化过程中细胞因子所起的作用。对 10 0例慢乙肝患者及 15例正常人群检测了血清TNF、IL - 2R、IL - 6、IL - 8、及HBVDNA定量等项指标。与对照组比较 ,各型慢乙肝患者血清TNF、IL - 2R、IL - 6、IL- 8含量均有不同程度升高 ,重度 >中度 >轻度。HBVDNA复制水平与血清TNF、IL - 2R、IL - 6水平及病程与血清TNF、IL - 2R、IL - 6、IL - 8水平均呈正相关。慢乙肝患者血清TNF、IL - 2R、IL - 6和IL - 8水平能够反映肝细胞损害的程度 ,在乙肝慢性化过程中 。
To investigate the role of cytokine in the chronicity of hepatitis B. We studied 100 cases of patients with chronic hepatitis B (CHB) and 15 normal people. The serum samples were collected and carried out for measurement of TNF, IL-2R, IL-6,IL-8 and HBV-DNA contents. Compared with the control, the serum TNF, IL-2R, IL-6, and IL-8 contents increased in the patients with CHB, severe CHB>moderate>mild. The duplicate level of HBV-DNA was positively correlated with TNF, IL-2R and IL-6 contents respectively and they are increased. with the disease-process prolonging. The serum TNF, IL-2R, IL-6, and IL-8 levels of CHB patients might reflect the extent of liver cell injury, and they all play various extents roles in the course of chronicity of hepatitis B.
出处
《临床肝胆病杂志》
CAS
北大核心
2003年第4期217-219,共3页
Journal of Clinical Hepatology
基金
山西省教委科学研究基金 (980 3 8)
