摘要
目的研究小儿止咳颗粒的急性和长期毒性。方法急性毒性采用小鼠最大耐受量(MTD)实验:长期毒性实验中给予大鼠高、中、低剂量的小儿止咳颗粒,连续给药90d,进行行为,血常规、血液生化、脏器指数、系统解剖检查与可逆性观察。结果急性毒性实验未见小鼠明显中毒症状,长期毒性实验中给予高、中、低剂量小儿止咳颗粒的大鼠外观体征,行为活动,体重、血常规、血液生化、脏器指数与系统解剖检查均未见异常,可逆性观察表明小儿止咳颗粒对大鼠未引起延迟性毒性与对照大鼠比较无显著性差异。结论小儿止咳颗粒对小鼠、大鼠的急性和长期毒性实验中对实质性器官无明显毒性作用,可供临床应用。
Objective To study the acute and long-term toxicity of Xiaoerzhike granules.Methods the maximum tolerance dose(MTD)on mice was used to detect the acute toxicity.Xiaoerzhike granules in high,medium and low dosages were given continuously to rats for 90 days in long-term toxicity trial to observe on behavior,blood cytology indexes,blood biochemical indicators,organ indexes,systemic anatomy examination and reversibility observation.Results no obvious indication of toxic symptom was observed in mice in the acute toxicity trial.The results of long-term toxicity trial indicate that there was no significant difference in appearances,behaviors and activities,body weights,blood cytology indexes,blood biochemical indexes,organ indexes and systemic anatomy examination in the rats of the three groups of high,medium and low dosages.The reversibility study demonstrates that there was no delayed toxicity caused in the rats of three dosage groups as compared to control group.Conclusion Xiaoerzhike granules have no significant toxic effect on substantial organs shown in the acute and long-term toxicity trials conducted on mice and rats,and may be provided for clinical applications.
出处
《环球中医药》
CAS
2014年第S2期1-2,共2页
Global Traditional Chinese Medicine
基金
深圳市医疗卫生类科研项目(201303092)
