摘要
目的探讨老年人轻度认知障碍(mild cognitive impairment,MCI)的危险因素及其与代谢综合征(metabolic syndrome,MS)的相关性。方法对2 500例年龄≥60岁老年人进行认知障碍调查,疑似MCI者共203例为MCI组,选择性别、年龄匹配的203例非MCI者为对照组,比较2组基线资料,分析其危险因素、MS各组分对MCI的影响。结果 MCI组体力活动≥60min/d比率(11.8%)、中文版简易智能状态检查量表评分(17.6±2.2)低于对照组(29.1%、24.9±2.6),合并MS(42.9%)、腹型肥胖(58.6%)、高甘油三酯血症(34.5%)、高血糖(28.6%)比率高于对照组(18.7%、41.9%、18.7%、17.2%)(P<0.05);logistic回归分析显示,高血压、MS、体力活动≥60min/d是MCI的影响因素(P<0.05),高血压、MS、体力活动≥60 min/d者MCI患病风险分别是未合并高血压、未合并MS和体力活动<60min/d的2.138倍(95%CI:1.034~4.422,P=0.040)、4.065倍(95%CI:1.845~8.954,P=0.001)、0.308倍(95%CI:0.174~0.540,P=0.000)。结论高血压、MS是MCI的独立危险因素,体力活动≥60min/d为MCI的保护因素。
Objective To investigate the risk factors for mild cognitive impairment(MCI)and the correlation between MCI and metabolic syndrome(MS)in the elderly.Methods A total of 2 500 elderly subjects aged 60 years or older received Chinese Version of Mini-mental State Examination(CMMSE),in which there were 203 patients with suspected MCI(MCI group)and 203age-and sex-matched patients without MCI(control group).The baseline data were compared between two groups to analyze the influence of risk factors and MS components on MCI.Results The proportion of physical activity≥60min/d(11.8%)and the mean score of CMMSE(17.6±2.2)were significantly lower,and the incidences of complicated MS(42.9%),abdominal obesity(58.6%),hypertriglyceridemia(34.5%)and hyperglycemia(28.6%)in MCI group were significantly higher than those in control group(29.1%,24.9±2.6,18.7%,41.9%,18.7%,17.2%)(P<0.05).Logistic regression analysis showed that hypertension,MS and physical activity ≥60min/d were the influencing factors for MCI.The risk of hypertension,MS and physical activity was 2.138(95%CI:1.034-4.422,P=0.040),4.065(95%CI:1.845-8.954,P=0.000)and 0.308(95%CI:0.174-0.540,P=0.000)times higher than those without hypertension,MS and physical activity< 60min/d.Conclusion Hypertension and MS are the independent risk factors for MCI,and physical activity≥60min/d is the protective factor for MCI in the elderly.
出处
《中华实用诊断与治疗杂志》
2017年第2期142-144,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家自然科学基金面上项目(81070958)
国家自然科学基金面上项目(81371218)
关键词
轻度认知障碍
代谢综合征
危险因素
Mild cognitive impairment
metabolic syndrome
risk factors
