摘要
目的了解年龄≥65岁的高干人员轻度认知功能障碍的患病情况及其相关危险因素,为进行有效防治提供参考依据。方法选取在广州市第一人民医院体检的老年高干454例为研究对象,分别给予简易精神状态量表(mini mental state examination,MMSE)的认知量表和蒙特利尔认知量表(Montreal cognitive assess-ment,MoCA)评估,进行两种量表得分相关性分析和MCI检出率比较。同时根据临床诊断标准将研究对象分为正常组(96名)和MCI组(337例),分析轻度认知功能障碍的相关危险因素。结果 MoCA和MMSE得分显著相关(r=0.563,P<0.01),MoCA检出率(78.98%)大于MMSE检出率(45.96%)。年龄、抑郁得分、收缩压、高血压在两组之间的差异有显著统计学意义(P<0.01)。MCI组中,年龄、高血压和抑郁得分均是MCI的独立危险因素(P<0.01)。结论老年高干人群中,年龄、高血压和抑郁均是MCI的独立危险因素,有针对性的对其干预可减少痴呆的发生。
Objective To Study on prevalence and risk factors of mild cognitive impairment （MCI） among retired people （age ≥65） in Guangzhou city. Methods Four hundred and fifty-four retired senior cadres were recruited from checkup clinic at the First Municipal People＇s Hospital. All subjects were evaluated using the MoCA and Mini Mental State Examination （MMSE）. All participants were further divided in normal （96 cases） and MCI groups （337 cases） based on MoCA and MMSE evaluation. Results MoCA and MMSE were highly correlated （r = 0.563, P 〈 0.01 ）. The detection rate of MoCA （78.98%） was higher than that of MMSE （45.96%）. There were significant differences in the age, depression scores, systolic pressure and hypertension between normal and MCI groups （P 〈 0.01）. The Age, hypertension and depres- sion scores were independent risk factors of MCI. Conclusions The Age, hypertension and depression were independent risk factors for MCI and early interventions aimed at controlling the modifiable risks may slow the transition of MCI to dementia in MCI patients.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2011年第8期473-476,共4页
Chinese Journal of Nervous and Mental Diseases
