摘要
目的 探讨血清糖类抗原125(CA125)、癌胚抗原(CEA)和糖类抗原19-9(CA19-9)检测对非小细胞肺癌(NSCLC)患者骨转移的预测价值。方法 选取2023年3月—2024年4月在第八师石河子市总医院城中分院规律复查的88例NSCLC患者作为研究对象。根据有无骨转移分为骨转移组(n=31)与无骨转移组(n=57),比较两组一般资料及血清CA125、CEA、CA19-9水平,绘制受试者工作特征(ROC)曲线,分析CA125、CEA、CA19-9以及联合检测对NSCLC患者骨转移的预测价值。结果 两组年龄和骨痛、脊髓或神经受压、高钙血症、碱性磷酸酶升高情况比较,差异有统计学意义(P<0.05);骨转移组血清CA125、CEA和CA19-9水平均高于无骨转移组,差异有统计学意义(P<0.05)。ROC曲线分析结果显示,对NSCLC患者骨转移预测价值血清CA125、CEA和CA19-9单独检测的曲线下面积(AUC)分别为0.673、0.741和0.568,3项联合检测的AUC为0.884,CA125+CEA检测的AUC为0.879,3项联合检测的AUC大于单独检测,差异有统计学意义(P<0.05);CA125+CEA检测的AUC大于单独检测,差异有统计学意义(P<0.05),但稍低于3项联合检测。结论 血清CA125、CEA和CA19-9检测对NSCLC患者骨转移均具有预测价值,且3项联合检测的预测价值高于单独检测。
Objective To investigate the predictive value of serum carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9)detections for bone metastasis in patients with non-small cell lung cancer(NSCLC).Methods A total of 88 NSCLC patients who were regularly reviewed in the Central Branch of the Eighth Division Shihezi General Hospital from March 2023 to April 2024 were selected as the research objects,and the patients were divided into bone metastasis group(n=31)and non-bone metastasis group(n=57)according to the presence or absence of bone metastasis.The general data,serum levels of CA125,CEA and CA19-9 were compared between the two groups.The receiver operating characteristic(ROC)curve was drawn,and the predictive value of CA125,CEA,CA19-9 and the combined detection for bone metastasis in NSCLC patients were analyzed.Results There were statistically significant differences in age,bone pain,spinal cord or nerve compression,hypercalcemia,and elevated alkaline phosphatase between the two groups(P<0.05).The serum levels of CA125,CEA and CA19-9 in bone metastasis group were higher than those in non-bone metastasis group,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the values of area under the curve(AUC)of serum CA125,CEA and CA19-9 alone in predicting bone metastasis in NSCLC patients were 0.673,0.741 and 0.568,respectively.The AUC of the three combined detection was 0.884,while the AUC of CA125 combined with CEA detection was 0.879.The AUC of the three combined detection was greater than those of single detection of the three indexes,and the differences were statistically significant(P<0.05).The AUC of CA125 combined with CEAdetection was greater than those of single detection of the three indexes,and the differences were statistically significant(P<0.05),but the AUC of CA125 combined with CEA detection was slightly lower than that of three combined detection.Conclusions Serum CA125,CEA and CA19-9 detections have predictive value for bone metastasis in NSCLC patients,and the predictive value of the combined detection of the three indexes is higher than those of single detection of the three indexes.
作者
李月华
LI Yuehua(Department of Clinical Laboratory,Central Branch of the Eighth Division Shihezi General Hospital,Shihezi,Xinjiang 832000,China)
出处
《医药前沿》
2025年第7期12-15,共4页
Journal of Frontiers of Medicine
关键词
非小细胞肺癌
骨转移
糖类抗原125
癌胚抗原
糖类抗原19-9
预测价值
受试者工作特征曲线
Non-small cell lung cancer
Bone metastasis
Carbohydrate antigen 125
Carcinoembryonic antigen
Carbohydrate antigen 19-9
Predictive value
Receiver operating characteristic curve
