摘要
人凝血因子Ⅸ是一种维生素K依赖性凝血糖蛋白,该物质是人体凝血瀑布中的活性成分,参与人体凝血过程,当血浆中人凝血因子Ⅸ含量或活性大幅下降时,内源性凝血途径受到阻碍,人体无法进行正常的凝血,从而引发血友病B。人凝血因子Ⅸ作为血友病B治疗药物被广泛使用。从人凝血因子Ⅸ与血友病的关系,该产品的生产工艺及发展历史,简要概括了该产品的国内外研究现状,为相关研究者提供清晰的认知,促进该产品的进一步发展。
Human coagulation factorⅨis a vitamin K-dependent coagulation protein,which is an active ingredient in the human coagulation cascade and participates in the human coagulation process.When the content or activity of human coagulation factorⅨin the plasma significantly decreases,the endogenous coagulation pathway is blocked,and the human body cannot perform normal coagulation,leading to hemophilia B.Human coagulation factorⅨis widely used as a therapeutic drug for hemophilia B.This article discusses the relationship between human coagulation factorⅨand hemophilia,as well as the production process and development history of this product,providing clear understanding for relevant researchers and promoting further development of the product.
作者
梁栋立
罗观文
陈振春
LIANG Dongli;LUO Guanwen;CHEN Zhenchun(Guangdong Shuan Lin Bio-pharmacy Co.,Ltd.,Zhanjiang 524000,China)
出处
《山东化工》
2024年第22期125-127,共3页
Shandong Chemical Industry
关键词
人凝血因子Ⅸ
血友病B
生产工艺
产品迭代
human coagulation factorⅨ
Hemophilia B
production process
product iteration
