摘要
目的研究注射用甲泼尼龙琥珀酸钠(商品名:甲强龙)在中重度支气管哮喘急性发作急救中的价值。方法选取116例中重度支气管哮喘急性发作患者,随机分为对照组与观察组,每组58例。对照组采用布地奈德治疗,观察组采用甲强龙治疗。比较两组疗效、肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、最大呼气流量(PEF)]、血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、血清总免疫球蛋白(IgE)与嗜酸性粒细胞(EOS)计数及生活质量。结果观察组55例有效(94.8%)、3例无效(5.2%);对照组38例有效(65.5%)、20例无效(34.5%)。观察组有效率高于对照组(P<0.05)。治疗后,观察组PEF为(6.15±0.27)L/s、FEV1为(2.64±0.14)L、FVC为(2.93±0.11)L;对照组PEF为(5.11±0.25)L/s、FEV1为(1.82±0.12)L、FVC为(2.35±0.14)L。治疗后,观察组PEF、FEV1及FVC均高于对照组(P<0.05)。治疗后,观察组PaO_(2)为(84.30±9.10)mm Hg(1 mm Hg=0.133 kPa)、PaCO_(2)为(34.10±2.10)mm Hg;对照组PaO_(2)为(77.20±11.10)mm Hg、PaCO_(2)为(43.10±5.60)mm Hg。治疗后,观察组PaO_(2)高于对照组、PaCO_(2)低于对照组(P<0.05)。治疗后,观察组血清EOS计数为(0.30±0.01)×10^(9)/L、总IgE为(106.80±9.70)U/ml;对照组血清EOS计数为(0.40±0.21)×10^(9)/L、总IgE为(146.20±8.20)U/ml。治疗后,观察组血清EOS计数、总IgE均低于对照组(P<0.05)。治疗后,观察组躯体功能、情感职能、总体健康、社会功能、精神健康、生理功能、活力、生理职能评分高于对照组(P<0.05)。结论中重度支气管哮喘急性发作急救时选择甲强龙可取得显著的疗效,临床可行。
Objective To study the value of methylprednisolone sodium succinate for injection(methylprednisolone)in emergency treatment of acute attacks of moderate to severe bronchial asthma.Methods 116 patients with acute attack of moderate to severe bronchial asthma were selected and randomly divided into a control group and an observation group,with 58 cases in each group.The control group was treated with budesonide,and the observation group was treated with methylprednisolone.Comparison was made on therapeutic effect,pulmonary function[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),peak expiratory flow(PEF)],blood gas index[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))],serum total immunoglobulin E(IgE)and eosinophil(EOS)count and quality of life between the two groups.Results In the observation group,55 cases(94.8%)were effective and 3 cases(5.2%)were ineffective;in the control group,38 cases(65.5%)were effective and 20 cases(34.5%)were ineffective.The effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the observation group had PEF of(6.15±0.27)L/s,FEV1 of(2.64±0.14)L and FVC of(2.93±0.11)L;the control group had PEF of(5.11±0.25)L/s,FEV1 of(1.82±0.12)L and FVC of(2.35±0.14)L.After treatment,PEF,FEV1 and FVC of the observation group were higher than those of the control group(P<0.05).After treatment,the observation group had PaO_(2)of(84.30±9.10)mm Hg(1 mm Hg=0.133 kPa)and PaCO_(2)of(34.10±2.10)mm Hg;the control group had PaO_(2)of(77.20±11.10)mm Hg and PaCO_(2)of(43.10±5.60)mm Hg.After treatment,PaO_(2)of the observation group was higher than that of the control group,and PaCO_(2)was lower than that of the control group(P<0.05).After treatment,the observation group had serum EOS count of(0.30±0.01)×10^(9)/L and total IgE of(106.80±.9.70)U/ml;the control group had serum EOS count of(0.40±0.21)×10^(9)/L and total IgE of(146.20±8.20)U/ml.After treatment,the serum EOS count and total IgE in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of bodily function,role-emotional,general health,social functioning,mental health,physical functioning,vitality,and role-physical in the observation group were higher than those in the control group(P<0.05).Conclusion Choosing methylprednisolone in emergency treatment for acute attacks of moderate to severe bronchial asthma has achieved significant therapeutic effects and is feasible.
作者
余飞
胡琪
YU Fei;HU Qi(Nanping Second Hospital,Nanping 354200,China)
出处
《中国现代药物应用》
2024年第23期108-111,共4页
Chinese Journal of Modern Drug Application
关键词
中重度支气管哮喘
急性发作
注射用甲泼尼龙琥珀酸钠
疗效
血气指标
肺功能
Moderate to severe bronchial asthma
Acute attack
Methylprednisolone sodium succinate for injection
Efficacy
Blood gas indicators
Pulmonary function
