摘要
In this manuscript we comment on the article by Yang et al published recently,focusing on how hepatic angiopoietin-2(Ang-2)transcription promote the pro-gression of hepatocellular carcinoma(HCC).HCC is one of the most common and lethal malignancies worldwide,especially in regions with high hepatitis B virus infection rates.Ang-2 is a key mediator of angiogenesis and plays a significant role in the progression of chronic liver diseases towards HCC,particularly in the hypoxic microenvironment.This paper reviews the dynamic expression of Ang-2 in hepatocarcinogenesis and its regulation by hypoxia-inducible factor-1α.Fur-thermore,we discuss Ang-2’s potential as an early monitoring biomarker for me-tastasis,and the therapeutic prospects of silencing hypoxia-inducible factor-1αto downregulate Ang-2 and suppress epithelial-mesenchymal transition in HCC treatment.
基金
Supported by the Basic and Clinical Integration Project of Xi’an Jiaotong University,No.YXJLRH2022067.
