摘要
目的探讨桑枝总生物碱片联合西药治疗2型糖尿病(type 2 diabetes mellitus,T2DM)合并冠心病(coronary heart disease,CHD)患者的效果及对患者糖脂代谢和炎性因子水平的影响。方法选取收治的T2DM合并CHD患者118例作为研究对象,用随机数字表法分为观察组和对照组,每组59例。对照组予以常规西药治疗,观察组在对照组治疗的基础上联合桑枝总生物碱片治疗,2组均连续治疗8周。比较治疗前后2组的糖脂代谢[空腹血糖(fasting blood-glucose,FPG)、稳态模型评估胰岛β细胞功能指数(homeostasis model assessment of insulinβ-cell function index,HOMA-β)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、血清总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)和低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)]的水平、炎性因子[血浆脂蛋白磷脂酶A2(lipoprotein-associated phospholipase A2,Lp-PLA2)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)和同型半胱氨酸(homocysteine,Hcy)]的水平,观察2组不良反应的发生情况。结果治疗后,观察组的FPG、HbA1c水平均低于对照组,HOMA-β水平高于对照组(P<0.05);观察组的TC、LDL-C水平均低于对照组,HDL-C水平高于对照组(P<0.05);观察组血浆Lp-PLA2、hs-CRP、Hcy水平均低于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论桑枝总生物碱片联合西药治疗T2DM合并CHD患者疗效显著,可有效改善糖脂代谢紊乱,降低炎性因子水平。
Objective To explore curative effect of Sangzhi Alkaloids combined with western medicines and its influences on glucose-lipid metabolism and inflammatory factors in patients with type 2 diabetes mellitus(T2DM)and coronary heart disease(CHD).Methods A total of 118 patients with T2DM and CHD were enrolled.According to random number table method,they were divided into an observation group(n=59,receiving Sangzhi Alkaloids combined with routine western medicines)and a control group(n=59,receiving routine western medicines).All were treated for 8 weeks.The levels of glucose-lipid metabolism indices[fasting blood glucose(FPG),homeostasis model assessment of insulinβ-cell function index(HOMA-β),glycosylated hemoglobin(HbA1c),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)]and inflammatory factors[lipoprotein assacited phospholipase A2(Lp-PLA2),high-sensitivity C-reactive protein(hs-CRP),and homocysteine(Hcy)]were compared between the 2 groups before and after treatment.The occurrence of adverse reactions was observed.Results After treatment,the levels of FPG and HbA1c in the observation group were lower than those in the control group,while HOMA-βwas higher than that in control group(P<0.05).The levels of TC and LDL-C in observation group were lower than those in control group,while HDL-C was higher than that in the control group(P<0.05).The levels of plasma Lp-PLA2,hs-CRP and Hcy in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion The curative effect of Sangzhi Alkaloids combined with western medicines is significant in patients with T2DM and CHD,which can effectively improve glucose-lipid metabolism disorders and reduce the levels of inflammatory factors.
作者
吴卫明
韩佳妮
钱玲玲
王莞秋
金艺璇
陈正方
WU Weiming;HAN Jiani;QIAN Lingling;WANG Guanqiu;JIN Yixuan;CHEN Zhengfang(Department of Endocrinology,Changshu Hospital of Traditional Chinese Medicine,Changshu 215500,China;Department of Endocrinology,Changshu First People’s Hospital,Changshu 215500,China)
出处
《西北药学杂志》
CAS
2024年第6期207-211,共5页
Northwest Pharmaceutical Journal
基金
常熟市科技计划项目(编号:KJXW2019060)。
关键词
桑枝总生物碱片
糖尿病
冠心病
糖脂代谢
炎性因子
Sangzhi Alkaloids
diabetes mellitus
coronary heart disease
glucose-lipid metabolism
inflammatory factor
