摘要
目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者磁共振扩散张量成像(DTI)表现及脑白质微结构变化与认知功能的相关性。方法选取2022年5月~2023年3月我院120例OSAS患者作为观察组,另选取120例健康体检者作为对照组。两组均行DTI扫描,并统计两组脑室周围白质高信号(PVH)、双侧半卵圆中心、双侧额叶、胼胝体压部、胼胝体膝部表观弥散系数(ADC)值及部分各向异性(FA)值,比较观察组不同认知功能障碍患者与认知功能正常患者临床资料、DTI表现、脑白质微结构,Logistic回归分析患者DTI表现、脑白质微结构变化与认知功能障碍关系,分析DTI表现及脑白质微结构变化与认知功能程度的相关性。结果观察组PVH评分、双侧额叶ADC值高于对照组,双侧额叶FA值低于对照组(P<0.05);轻度、中重度认知功能障碍患者年龄、BMI及OSAS病情程度与认知功能正常患者比较,差异显著(P<0.05);中重度认知功能障碍患者PVH评分、双侧额叶ADC值>轻度认知功能障碍患者>认知功能正常患者,双侧额叶FA值<轻度认知功能障碍患者<认知功能正常患者(P<0.05);Logistic显示,PVH评分、双侧额叶ADC值、FA值与OSAS患者认知功能障碍有关(P<0.05);OSAS患者PVH评分、双侧额叶ADC值与认知功能程度呈正相关,双侧额叶FA值与认知功能程度呈负相关(P<0.05)。结论OSAS患者脑白质结构损害、双侧额叶FA及ADC值与认知功能严重程度密切相关,可用作OSAS患者评估认知功能的主要依据。
Objective To investigate the correlation between magnetic resonance diffusion tensor imaging(DTI),white matter microstructure and cognitive function in patients with obstructive sleep apnea syndrome(OSAS).Methods 120 patients with OSAS in our hospital from May 2022 to March 2023 were selected as the observation group,and 120 healthy subjects were selected as the control group.DTI scanning was performed in both groups,and the values of periventricular white matter high signal(PVH),bilateral hemioval center,bilateral frontal lobe,pressure part of corpus callosum,apparent diffusion coefficient(ADC)and partial anisotropy(FA)were counted in both groups.The clinical data,DTI performance and white matter microstructure of patients with different cognitive dysfunction and patients with normal cognitive function were compared in the observation group.Logistic regression analysis was conducted to analyze the relationship between DTI performance,white matter microstructure changes and cognitive dysfunction,and the correlation between DTI performance and white matter microstructure changes and cognitive function degree.Results The PVH score and ADC value of bilateral frontal lobes in the observation group were higher than those in the control group,and the FA value of bilateral frontal lobes was lower than that in the control group(P<0.05).There were significant differences in age,BMI and OSAS between mild and moderate to severe cognitive impairment patients and normal cognitive function patients(P<0.05).PVH score and bilateral frontal ADC value in patients with moderate to severe cognitive dysfunction were higher than those with mild cognitive dysfunction>those with normal cognitive function,and bilateral frontal FA value was lower than those with mild cognitive dysfunction<those with normal cognitive function(P<0.05).Logistic showed that PVH score,bilateral frontal ADC value and FA value were correlated with cognitive dysfunction in OSAS patients(P<0.05).In OSAS patients,PVH score and bilateral frontal ADC were positively correlated with the degree of cognitive function,while bilateral frontal FA value was negatively correlated with the degree of cognitive function(P<0.05).Conclusion White matter structure damage,bilateral frontal FA and ADC values in OSAS patients are closely related to the severity of cognitive function,which can be used as the main basis for the assessment of cognitive function in OSAS patients.
作者
孙瑾
李艳捧
赵雅珍
张兰
SUN Jin;LI Yan-peng;ZHAO Ya-zhen;ZHANG Lan(Department of Medical Imaging,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei Province,China;MRI Room,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei Province,China)
出处
《中国CT和MRI杂志》
2024年第11期23-26,共4页
Chinese Journal of CT and MRI
基金
河北省医学科学研究重点课题计划项目(20231422)。
