摘要
目的探讨血清组蛋白脱乙酰酶2(HDAC2)、Toll样受体2(TLR2)水平对老年重症肺炎(SP)合并呼吸衰竭(RF)患者预后的评估效能。方法选择2020年4月至2023年5月新乡医学院第一附属医院收治的96例老年SP合并RF患者作为观察组,选择同期我院健康体检者96名作为对照组。根据疾病转归情况将观察组患者分为存活组(n=74)与死亡组(n=22)。采用酶联免疫吸附法(ELISA)检测所有研究对象血清HDAC2、TLR2表达水平,采用受试者工作特征(ROC)曲线评估血清HDAC2、TLR2水平对老年SF合并RF患者预后的评估价值。结果观察组血清HDAC2、TLR2水平高于对照组,死亡组血清HDAC2、TLR2水平高于存活组,差异有统计学意义(P<0.05)。血清HDAC2、TLR2水平评估SP合并RF患者预后的AUC分别为0.796(95%CI:0.751~0.846)、0.822(95%CI:0.778~0.872),两者联合评估的AUC为0.914(95%CI:0.859~0.964)。结论血清HDAC2、TLR2水平在SP合并RF预后死亡患者中均表达上调,二者与SP合并RF患者预后死亡存在一定关系,联合检测可以提高对SP合并RF患者预后情况的评估价值。
Objective To investigate the efficacy of serum histone deacetylase 2(HDAC2)and Toll-like receptor 2(TLR2)levels on evaluating the prognosis of elderly patients with severe pneumonia(SP)complicated with respiratory failure(RF).Methods Ninety-six elderly patients with SP combined with RF admitted to the First Affiliated Hospital of Xinxiang Medical College from April 2020 to May 2023 were selected as the observation group,and 96 healthy physical examination subjects in our hospital during the same period were selected as the control group.According to the disease outcome,the observation group was divided into survival group(n=74)and death group(n=22).The expression levels of serum HDAC2 and TLR2 in all subjects were detected by enzymal-linked immunosorbent assay(ELISA),and the prognostic evaluation value of serum HDAC2 and TLR2 levels for elderly patients with SF combined with RF was evaluated by receiver operating characteristic(ROC)curve.Results The serum HDAC2 and TLR2 levels in observation group were higher than those in control group,and those in death group were higher than those in survival group,the differences were significant(P<0.05).The AUC of serum HDAC2 and TLR2 in evaluating the prognosis of SP patients with RF was 0.796(95%CI:0.751~0.846)and 0.822(95%CI:0.778~0.872),respectively,and the AUC of the combined evaluation was 0.914(95%CI:0.859~0.964).Conclusions Serum HDAC2 and TLR2 levels are up-regulated in cases with SP combined with RF prognostic death,and there is a certain relationship between them and prognostic death of cases with SP combined with RF.Combined detection can improve the evaluation value of prognosis of patients with SP combined with RF.
作者
赵沙沙
王圆圆
张春丽
陈雪阳
冯宪军
Zhao Shasha;Wang Yuanyuan;Zhang Chunli;Chen Xueyang;Feng Xianjun(Respiratory Intensive Care Unit,the First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,China)
出处
《临床医学》
CAS
2024年第10期25-27,共3页
Clinical Medicine
