摘要
目的:探讨滥用甲基苯丙胺强制隔离戒毒人员急性脱毒期和出所期心电图特点。方法:以大队为单位,整群随机抽取湖南省4所强制隔离戒毒所2018年9月至2022年10月期间的甲基苯丙胺滥用者1225人作为研究对象。按照入所时间将甲基苯丙胺滥用者分为急性脱毒组和出所组,选取593名社会体检人员作为对照组,同时将各组按照性别分成男女两组。收集所有研究对象的心电图,进行急性脱毒组、出所组、对照组之间和各组男女性之间心电图分析。结果:急性脱毒组、出所组、对照组心电图异常率比较,差异有统计学意义(P<0.05)。急性脱毒组男女性的窦性心动过速、异常ECG人数比较,差异有统计学意义(P<0.05),且男性高于女性;出所组男女性窦性心动过缓并不齐人数比较,差异有统计学意义(P<0.05),且女性高于男性。此外,急性脱毒组内滥用时间小于15年的男女性心电图异常率比较,差异无统计学意义(P>0.05);而滥用时间大于15年的男女性心电图异常率差异有统计学意义(P<0.05),且男性高于女性。结论:甲基苯丙胺可对滥用者心脏造成长期损伤,随着滥用时间增加,对男性的损伤更加明显。在强制隔离戒毒场所,精神心理因素对滥用者窦房结主要产生抑制作用,且对女性的抑制作用更加明显。
Objective:To explore the electrocardiogram characteristics of methamphetamine abusers in Compulsory Isolated Detoxification Centers during the acute detoxification and discharge periods.Methods:Cluster randomly sampled 1,225 methamphetamine abusers from four compulsory Isolated Detoxification centers in Hunan Province between September 2018 and October 2022 as study subjects on a brigade basis.The methamphetamine abusers were divided into acute detoxification group and discharge group according to the admission time,593 social medical examiners were selected as the control group,and the groups were also divided into men and women according to gender.Electrocardiograms of all study subjects were collected and analyzed among the acute detoxification group,discharge group,control group and between male and female in each group.Results:There was a statistically significant difference in the abnormal rate of electrocardiogram between the acute detoxification group,the exit group and the control group(P<0.05).There were significant differences in the number of sinus tachycardia and abnormal electrocardiogram between men and women in the acute detoxification group(P<0.05),and the number of men was higher than that of women.There was a statistically significant difference in the number of sinus bradycardia and arrhythmia between men and women in the study group(P<0.05),and women were higher than men.In addition,there was no significant difference in the abnormal rate of electrocardiogram between men and women with abuse time less than 15 years in the acute detoxification group(P>0.05).There was a statistically significant difference in the abnormal rate of electrocardiogram between men and women who abused for more than 15 years(P<0.05),and men were higher than women.Conclusion:Methamphetamine can cause long-term damage to the heart of abusers.With the increase of abuse time,the damage to men is more obvious.In the compulsory isolation detoxification place,psychological factors mainly inhibit the sinus node of abusers,and the inhibition effect on women is more obvious.
作者
王文武
李广迪
WANG Wenwu;LI Guangdi(Hunan provincial Lushan Compulsory Isolated Detoxification Center,Hunan Provincial 519 Hospital,Changsha 410208,Hunan,China;Xiangya School of Medicine,Central South University,Changsha 410013,Hunan,China)
出处
《中国药物滥用防治杂志》
CAS
2024年第9期1586-1590,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
湖南省戒毒管理局教育矫正优势项目(编号:JYJZ2022015)。
关键词
强制隔离戒毒
甲基苯丙胺
滥用者
心电图
Compulsory isolated detoxification
Methamphetamine
Abuser
Electrocardiogram
