摘要
Despite the promising prospects of nanoparticles in oral drug delivery,the process of oral administration involves a complex transportation pathway that includes cellular uptake,intracellular trafficking,and exocytosis by intestinal epithelial cells,which are necessary steps for nanoparticles to enter the bloodstream and exert therapeutic effects.Current researchers have identified several crucial factors that regulate the interaction between nanoparticles and intestinal epithelial cells,including surface properties such as ligand modification,surface charge,hydrophilicity/hydrophobicity,intestinal protein corona formation,as well as holistic properties like particle size,shape,and rigidity.Understanding these properties is essential for enhancing transepithelial transport efficiency and designing effective oral drug delivery systems.Therefore,this review provides a comprehensive overview of the surface and holistic properties that influence the transepithelial transport of nanoparticles,elucidating the underlying principles governing their impact on transepithelial transport.The review also outlines the chosen of parameters to be considered for the subsequent design of oral drug delivery systems.
基金
the National Natural Science Foundation of China(82104069)
the Regional Innovation and Development Joint Fund of the National Natural Science Foundation of China(U22A20356)
the JapaneChina Sasakawa Medical Fellowship,Sichuan Science and Technology Department Project(2022089)
Sichuan Medical Association Youth Innovation Research Project(Q20019)
the Third People’s Hospital of Chengdu Scientific Research Project(2023PI16)
Clinical Research Program(CSY-YN-01-2023-015).
