摘要
代谢相关脂肪性肝病(MAFLD)作为一种常见肝病,发病机制复杂,但多与机体代谢障碍有关,如高脂血症、肥胖、胰岛素抵抗等。脾的运化功能与机体代谢的关系已被多次证实,中医学也认为MAFLD虽病位在肝,但与脾密切相关。现代研究发现以铁代谢紊乱为基础的铁死亡在MAFLD向炎症、纤维化进展中起到重要作用。本文基于传统医学的土壅木郁理论,从铁死亡发生过程中铁代谢及脂质过氧化物聚集机制分析中医学的肝与脾在MAFLD发生发展中的作用,提出健脾疏肝可通过抑制铁死亡从而起到防治MAFLD作用的新途径。
As a common liver disease,Metabolic-associated fatty liver disease(MAFLD)has a complex pathogenesis but is mostly associated with metabolic disorders,such as hyperlipidemia,obesity,and insulin resistance.The relationship between the transport function of the spleen and body metabolism has been confirmed many times.Traditional Chinese medicine also believes that MAFLD is closely related to the spleen,although it is located in the liver.Modern studies have found that ferroptosis based on iron metabolism disorders plays an important role in the progression of MAFLD to inflammation and fibrosis.Based on the theory of“earth stagnation and wood depression”,in this paper,the role of liver and spleen in traditional Chinese medicine in the occurrence and development of MAFLD was analyzed from the mechanism of iron metabolism and lipid peroxide aggregation during the occurrence of ferroptosis,and also proposed a new way to soothing liver and invigorating spleen to prevent and treat MAFLD by inhibiting ferroptosis.
作者
黄玉迎
杨培伟
王晓杰
刘镇亚
赵文霞
HUANG Yuying;YANG Peiwei;WANG Xiaojie;LIU Zhenya;ZHAO Wenxia(The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《陕西中医》
CAS
2024年第10期1395-1398,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
国家自然科学基金资助面上项目(81473651)
河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020024)。
关键词
土壅木郁
铁死亡
代谢相关脂肪性肝病
非酒精性脂肪性肝病
健脾疏肝
铁代谢
Earth stagnation and wood depression
Ferroptosis
Metabolic-associated fatty liver disease
Non-alcoholic fatty liver disease
Soothing liver and invigorating spleen
Iron metabolism
