摘要
前蛋白转化酶枯草溶菌素-kexin9型抑制剂(PCSK9抑制剂)不仅具有良好的降脂作用,还具有改善心血管结局、减轻氧化应激及改善血管内皮等多效性作用。近年来,PCSK9抑制剂的不断研发为心血管疾病治疗提供了新思路,本文就PCSK9抑制剂的多效性作用机制研究,尤其是对于血管内皮功能的作用机制研究予以综述。
Proprotein convertase subtilisin/kexin type 9(PCSK9)inhibitors not only have good lipid-lowering effects,but also have pleiotropic effects such as improving cardiovascular outcomes,relieving anti-inflammation,relieving oxidative stress and improving vascular endothelium.In recent years,the continuous development of PCSK9 inhibitors provides new ideas for the treatment of cardiovascular diseases.This article reviewed the pleiotropic mechanisms of PCSK9 inhibitors,especially on vascular endothelial function.
作者
冯艳
罗文平
张明明
佘林聪
王家欣
孙涌鑫
陈昊青
张薇
FENG Yan;LUO Wengping;ZHANG Mingming;SHE Lincong;WANG Jiaxin;SUN Yongxin;CHEN Haoqing;ZHANG Wei(Department of Cardiovascular Medicine,the Second Affiliated Hospital of Air Force Medical University,Xi′an,Shaanxi,710038;Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi,712046)
出处
《实用临床医药杂志》
CAS
2024年第15期142-148,共7页
Journal of Clinical Medicine in Practice
基金
国家自然科学基金面上项目(82270366)。
关键词
前蛋白转化酶枯草溶菌素-kexin9型抑制剂
血管内皮
多效性
血脂
心血管结局
炎症
氧化应激
自噬
proprotein convertase subtilisin/kexin type 9 inhibitor
vascular endothelium
pleiotropy
blood lipids
cardiovascular outcomes
inflammation
oxidative stress
autophagy
