摘要
目的观察加味荆防方联合西替利嗪治疗慢性荨麻疹的效果。方法选择广东省中医院收治的114例慢性荨麻疹患者,采用随机数表法分为对照组与观察组,各57例,其中对照组脱落1例。对照组给予西替利嗪治疗,观察组在对照组基础上联合加味荆防方治疗,连续治疗4周,评估2组治疗效果。统计2组疗效、不良反应和复发率,检测2组趋化因子及免疫平衡指标水平,比较2组UAS积分、荨麻疹症状评分、中医证候评分、UCT评分、DLQI评分差异。结果观察组临床疗效总有效率(89.47%,51/57)高于对照组(75.00%,42/56)(P<0.05)。与治疗前比较,2组治疗后Eotaxin-1、TNF-α、IL-2、RANTES、IL-4、PARC/CCL-18、IL-13、Eotaxin-3、IL-33含量降低,IFN-γ升高,与对照组比较,观察组治疗后IFN-γ升高,其他指标均降低(P<0.05)。2组治疗后UCT评分高于治疗前,中医证候评分、DLQI评分、UAS积分、荨麻疹症状评分低于治疗前,观察组治疗后UCT评分高于对照组,其他评分均低于对照组(P<0.05)。2组不良反应率比较,差异无统计学意义(P>0.05)。2组复发率比较,差异有统计学意义(P<0.05)。结论加味荆防方联合西替利嗪治疗慢性荨麻疹可减轻荨麻疹症状,可能与调节趋化因子,促进Th1/Th2免疫平衡有关。
Objective To observe the effect of modified Jingfang prescription combined with cetirizine in the treatment of chronic urticaria(CU).Methods A total of 114 patients with chronic urticaria admitted to our hospital were divided into two groups by the random number table method,with 57 cases in each group.The control group was treated with cetirizine,while the observation group was treated with the modified Jingfang prescription on the basis of cetirizine,both for 4 weeks.The efficacy,adverse reactions and recurrence rates of the two groups were analyzed,the levels of chemokines and immune balance indexes of the two groups were detected,and the differences in UAS scores,urticaria symptom scores,TCM syndrome scores,UCT scores and DLQI scores were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of Eotaxin-1,TNF-α,IL-2,RANTES,IL-4,PARC/CCL-18,IL-13,Eotaxin-3 and IL-33 were lower in both groups than before treatment,while the level of IFN-γwas higher than before treatment,and the level of IFN-γwas much higher in the observation group than that in the control group,while the other indexes were much lower than those of the control group(P<0.05).After treatment,the UCT scores of the two groups were higher than before treatment,while the TCM syndrome scores,DLQI scores,UAS scores,and urticaria symptom scores were lower than before treatment,and the UCT scores were higher in the observation group than those in the cetirizine group,while the other scores were lower than those in the control group(P<0.05).There was no significant difference in the adverse reaction rate between the control group and the observation group(P>0.05),while there was a significant difference in the recurrence rate between the two groups(P<0.05).Conclusion Treating chronic urticaria with modified Jingfang prescription combined with cetirizine can alleviate the symptoms of urticaria,which may be related to regulating chemokines and promoting Th1/Th2 immune balance.
作者
王亚新
罗俊娜
吴梅丽
WANG Yaxin;LUO Junna;WU Meili(Department of Pharmacy,Guangdong Hospital of Traditional Chinese Medicine,Guangzhou 510000,China;Nancun Community Health Service Center of Panyu District,Guangzhou 511442,China;Department of Internal Medicine,Shiqiao Hospital,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 511400,China)
出处
《吉林中医药》
2024年第9期1064-1068,共5页
Jilin Journal of Chinese Medicine
基金
广东省自然科学基金项目(2020A1515010512)。
