摘要
目的:运用数据挖掘技术探究并总结韩明向教授辨治郁证的用药经验。方法:收集韩明向门诊郁证患者的病例,运用 Excel软件建立数据库,对病人年龄、性别、辨证证型、以及高频药物进行统计学分析,并用SPSS软件进行关联规则分析、频数项集分析、聚类分析。结果:共收录处方108例,好发人群为绝经期前后的女性和中青年及中年男性,证型最多的为气郁化火证。涉及药物189味,高频药物包括柴胡、当归、白芍、甘草、牡丹皮、栀子等;常用药对有茯神-合欢皮、酸枣仁-合欢皮、栀子-牡丹皮等;常用药物组合有酸枣仁、柴胡-合欢皮,茯神、夏枯草-合欢皮,茯神、栀子-合欢皮等。聚类分析得出栀子-牡丹皮-当归-白芍-柴胡、合欢皮-茯神-夏枯草等4个药物聚类组合。结论:韩明向教授秉承“治病必求于本”的学术思想,抓住郁证中气郁之关键,结合当代好发人群的生理及外在特点,从郁、气、火三方面形成行气解郁,疏肝泻火为主要治疗准则的临床经验。
Objective:To explore and summarize Professor HAN Mingxiang’s experience in using drugs to treat depression using data mining technology.Methods:Cases of depression patients in HAN Mingxiang’s outpatient clinic were collected,and a database was established using Excel software.The age,gender,syndrome type,and high-frequency drugs of the patients were statistically analyzed.SPSS software was used for association rule analysis,frequency item set analysis,and cluster analysis.Results:A total of 108 prescriptions were included.The most common populations were women before and after menopause and young and middle-aged men.The most common syndrome was Qi stagnation and fire syndrome.A total of 189 drugs were involved.The high-frequency drugs included bupleurum,angelica,white peony root,liquorice,peony bark,gardenia,etc.;the commonly used drug pairs included poria-albizzia bark,jujube seed-albizzia bark,gardenia-peony bark,etc.;the commonly used drug combinations included jujube seed,bupleurum-albizzia bark,poria,prunella vulgaris-albizzia bark,poria,gardenia-albizzia bark,etc.Cluster analysis resulted in four drug cluster combinations:Gardenia-Peony Root-Angelica-White Peony Root-Bupleurum,Albizzia julibrissin-Poria-Prunella Vulgaris.Conclusion:Professor HAN Mingxiang adheres to the academic thought of"the root of the disease must be sought",grasps the key of Qi stagnation in depression,combines the physiological and external characteristics of the contemporary susceptible population,and forms clinical experience of promoting Qi and relieving depression, soothing the liver and purging fire as the main treatment principles from the threeaspects of depression, Qi and fire.
作者
王雪东
侯志峰
韩明向
韩辉
WANG Xuedong;HOU Zhifeng;HAN Mingxiang;HAN Hui(The First Clinical Medical College of Anhui University of Traditional Chinese Medicine,Anhui Hefei 230038,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China)
出处
《中医药临床杂志》
2024年第7期1299-1304,共6页
Clinical Journal of Traditional Chinese Medicine
基金
2023年度安徽省卫生健康科研项目(AHWJ2023A20281)
第七批全国老中医药专家学术经验继承项目(国中医药人教函[2022]76号)
2022年中国民族医药学会科研项目(2022Z1002-450813)
2022年度安徽省中医药传承创新项目(2022CCZD01)。
关键词
国医大师韩明向
郁证
数据挖掘
HAN Mingxiang
Master of traditional Chinese medicine
Depression
Data mining
