摘要
目的探究子宫内膜癌(EC)患者血清泛素耦联酶2C(UBE2C)、三基序蛋白27(TRIM27)表达水平及其与病理参数的相关性。方法选取医院2020年3月至2023年3月96例EC患者为EC组,同期子宫内膜非典型增生(EAH)患者65例为EAH组,体检健康者80例为对照组。酶联免疫法分析血清UBE2C、TRIM27水平。ROC曲线分析血清UBE2C、TRIM27水平评估EC发生的预测价值。结果EC患者血清UBE2C、TRIM27水平显著高于体检健康者(P<0.05)。EC患者血清UBE2C、TRIM27水平与肿瘤直径、肿瘤分化程度、淋巴结转移、FIGO分期、肌层浸润深、宫颈受累、雌激素受体表达、孕激素受体表达有关(P<0.05)。血清UBE2C与TRIM27水平呈正相关(r=0.475,P<0.001);血清UBE2C、TRIM27水平与肿瘤直径、淋巴结转移、FIGO分期、肌层浸润深度呈正相关,与肿瘤分化程度、雌激素受体表达、孕激素受体表达呈负相关(P<0.05)。UBE2C、TRIM27联合评估EC发生的AUC显著高于单项检测(ZUBE2C-联合=3.406,P<0.001,ZTRIM27-联合=3.285,P=0.001)。结论EC患者血清UBE2C、TRIM27表达水平上调,与病理参数密切相关,血清UBE2C、TRIM27水平可为早期诊断EC提供参考。
Objective To investigate the expression level of serum ubiquitin-conjugating enzyme 2C(UBE2C)and tripartite motif-containing protein 27(TRIM27)in patients with endometrial cancer(EC)and their correlation with pathological parameters.Methods A total of 96 EC patients from March 2020 to March 2023 were selected as EC group;65 patients with endometrial atypical hyperplasia(EAH)as EAH group,and 80 healthy subjects as the control group.Enzyme linked immunosorbent assay was applied to analyze the expression level of serum UBE2C and TRIM27.The relationship between serum UBE2C,TRIM27,and pathological data was analyzed;receiver operating characteristic was applied to evaluate the predictive value of serum UBE2C and TRIM27 level for EC.Results The level of serum UBE2C and TRIM27 of EC patients was obviously higher than that in healthy subjects(P<0.05),and was correlated with tumor diameter,tumor differentiation,lymph node metastasis,FIGO stage,muscle layer invasion depth,cervical involvement,estrogen receptor expression,and progestogen receptor expression(P<0.05).There was positive correlation between serum UBE2C and TRIM27(r=0.475,P<0.001);and the level of serum UBE2C and TRIM27 was positively correlated with tumor diameter,lymph node metastasis,FIGO stage,and depth of musclular invasion,but negatively with tumor differentiation,estrogen receptor expression,and progestogen receptor expression(P<0.05).The combination of UBE2C and TRIM27 had obviously higher AUC in evaluating EC than single detection(ZUBE2C-combination=3.406,P<0.001,ZTRIM27-combination=3.285,P=0.001).Conclusion The expression level of UBE2C and TRIM27 in serum of EC patients is up-regulated,which is closely related to pathological parameters.The level of serum UBE2C and TRIM27 can provide reference for early diagnosis of EC.
作者
柴菲
陈振文
刘宏艳
李肃
龚媛媛
赵莹莹
CHAI Fei;CHEN Zhenwen;LIU Hongyan;LI Su;GONG Yuanyuan;ZHAO Yingying(Teaching and Research Office of Pathology,Fenyang College,Shanxi Medical University,Fenyang 032200,China;Department of Pathology,Fenyang Hospital,Fenyang 032200,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2024年第13期1808-1813,共6页
The Journal of Practical Medicine
基金
山西省卫生健康委员会项目(编号:2020TD12)。
关键词
子宫内膜癌
泛素耦联酶2C
三基序蛋白27
病理参数
相关性
endometrial cancer
ubiquitin-conjugating enzyme 2C
tripartite motif-containing protein 27
pathological parameters
correlation
