摘要
急性肺损伤(acute lung injury,ALI)是临床常见的极危重症之一,其死亡率与发病率居高不下,早期以低氧血症、肺间质水肿及肺部炎症为主,后进一步发展成为急性呼吸窘迫综合症,表现为严重的缺氧性呼吸衰竭。氧化应激作为诱发ALI的作用机制之一,在其发生发展中扮演重要作用。中药可通过抑制炎症及氧化应激反应,减轻肺间质水肿,改善肺通气,恢复肺组织损伤等起到治疗ALI的作用。基于此,从氧化应激作用功能、调控ALI机制及中药干预机制等方面进行归纳总结,为ALI的临床研究及新药创新探索提供理论指导。
Acute lung injury(ALI)is one of the most common and critically ill diseases in clinical practice,with high mortality and morbidity.It is mainly characterized by hypoxemia,pulmonary interstitial edema and pulmonary inflammation in the early stage,and further develops into acute respiratory distress syndrome in the later stage,which is manifested as severe hypoxic respiratory failure.As one of the mechanisms inducing ALI,oxidative stress plays an important role in its occurrence and development.Traditional Chinese medicine can play a role in treating ALI by inhibiting inflammation and oxidative stress,alleviating pulmonary interstitial edema,improving lung ventilation,and restoring lung tissue damage.Based on this,this paper summarized the function of oxidative stress,the mechanism of regulating ALI and the intervention mechanism of traditional Chinese medicine,in order to provide theoretical guidance for clinical research and new drug innovation exploration of ALI.
作者
张茂福
张志明
宋忠阳
张昺磊
沈雁云
刘叶元
李欣钰
ZHANG Maofu;ZHANG Zhiming;SONG Zhongyang;ZHANG Binglei;SHEN Yanyun;LIU Yeyuan;LI Xinyu(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of Chinese Medicine,Lanzhou 730050,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,China)
出处
《中草药》
CAS
CSCD
北大核心
2024年第9期3190-3201,共12页
Chinese Traditional and Herbal Drugs
基金
甘肃省科技重大专项-科技领军人才(21ZDKA0014)
高端人才承担省级科技计划项目(“长江学者奖励计划”)(甘科计[2021]20号-9)
甘肃省科技重大专项(甘科计[2022]1号-25)
甘肃省教育科技创新项目(2022B-108)
兰州市人才创新创业基金资助项目(2021-RC-80)。
