摘要
皂苷类成分在人参、三七、柴胡等多种中药中广泛存在,具有抗炎、抗氧化、抗肿瘤、保肝降脂、降血糖等多种生物活性,在急性肺损伤、高脂血症、糖尿病心血管并发症等疾病的预防和治疗中发挥重要作用,有较高的研究潜力和价值。代谢相关脂肪性肝病是以肝细胞中过度脂质积累为特征的临床多发慢性肝病,“多重打击”学说认为其发生是全身稳态失调的结果,受脂质代谢异常、氧化应激、炎症、胰岛素抵抗、线粒体功能障碍及肠道微生物群等多种因素的影响,但临床尚无有效治疗药物。近年研究发现,中药皂苷可通过调节脂质代谢异常、抑制炎症反应、缓解氧化应激、减轻胰岛素抵抗、改善线粒体功能障碍、调节肠道菌群、抑制肝细胞程序性死亡、调节肝脏自噬和调控免疫失衡等多种途径缓解代谢相关脂肪性肝病。因此,对近年中药皂苷改善代谢相关脂肪性肝病的药理作用与相关机制研究进行了归纳总结,以期为中药皂苷防治代谢相关脂肪性肝病的临床应用与实验研究提供一定的参考。
Saponins are widely found in various Chinese medicines such as Ginseng Radix et Rhizoma,Notoginseng Radix et Rhizoma,and Bupleuri Radix.They possess multiple biological activities,including antiinflammatory,antioxidant,antitumor,hepatoprotective,lipid-lowering,and hypoglycemic effects.They play an important role in the prevention and treatment of diseases such as acute lung injury,hyperlipidemia,and diabetic cardiovascular complications,and hold significant research potential and value.Metabolism-related fatty liver disease is a prevalent chronic liver disease characterized by excessive lipid accumulation in hepatocytes.According to the"multiple hit"theory,its occurrence is the result of systemic homeostasis disorder,influenced by abnormal lipid metabolism,oxidative stress,inflammation,insulin resistance,mitochondrial dysfunction,and intestinal microbiota.However,there is currently no effective treatment available in clinical practice.Recent studies have found that Chinese herbal saponins can alleviate metabolism-related fatty liver disease through various pathways,including regulating abnormal lipid metabolism,inhibiting inflammatory responses,alleviating oxidative stress,reducing insulin resistance,improving mitochondrial dysfunction,modulating intestinal flora,inhibiting hepatocyte programmed death,regulating liver autophagy,and correcting immune imbalances.Therefore,this review summarized the pharmacological effects and related mechanisms of Chinese herbal saponins in improving metabolism-related fatty liver disease in recent years,aiming to provide a theoretical reference for the clinical application and experimental research of Chinese herbal saponins in the prevention and treatment of metabolism-related fatty liver disease.
作者
王琳琳
朱正望
赵静涵
朱平生
苗明三
WANG Linlin;ZHU Zhengwang;ZHAO Jinghan;ZHU Pingsheng;MIAO Mingsan(Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第19期273-281,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(82074340)
河南省“双一流”创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-19)。
关键词
中药皂苷
代谢相关脂肪性肝病
脂质代谢
氧化应激
肠道菌群
Chinese herbal saponins
metabolism-associated fatty liver disease
lipid metabolism
oxidative stress
intestinal flora
