摘要
目的:采用度中心度(DC)和格兰杰因果分析(GCA)方法研究急性一氧化碳中毒(ACMP)患者脑功能网络有效连接变化,探索其与认知功能障碍之间的相关性。方法:对54例ACMP患者(ACMP组)及37名健康对照组(HC组)行静息态功能磁共振成像扫描,在两组间DC值具有显著差异的脑区中,选取左侧颞下回作为种子点,进行全脑体素GCA分析;提取组间具有显著差异的脑区DC值和GCA有效连接值,分析它们与MMSE、MoCA评分之间的相关性。结果:与HC组比较,ACMP组左侧颞下回、左侧海马、左侧海马旁回、左侧额上回、左侧额下回的DC值增高,右侧辅助运动区、右侧小脑Crus1区及Crus2区的DC值减低(P<0.05,FWE校正);左侧颞下回与双侧楔前叶、右侧颞下回及左侧中央旁小叶的双向有效连接效应均存在异常,另外左侧颞下回至右侧顶上回和双侧小脑Crus1区有效连接增强,至双侧扣带回、左侧额上回、左侧额中回有效连接减弱,而右侧中央旁小叶至左侧颞下回的有效连接减弱(P<0.05,GRF校正);相关分析显示,网络有效连接的变化与MoCA、MMSE评分有相关性(P<0.05)。结论:ACMP患者在脑网络中表现出异常程度的度中心性,主要在默认网络、中央执行网络、感觉运动网络间出现有效功能连接异常,提示患者在早期即存在全脑多功能网络损伤。
Objective:To study the changes of effective connections of brain functional networks in patients with acute carbon monoxide poisoning(ACMP)by using degree centrality(DC)and Granger causality analysis(GCA),and to explore the correlation between effective connections and cognitive impairment.Methods:54 ACMP patients(ACMP group)and 37 healthy controls(HC group)were scanned by resting-state functional magnetic resonance imaging(rs-fMRI).In the brain regions with significant differences in DC values between the two groups,the left inferior temporal gyrus was selected as the seed point for whole brain voxel GCA analysis,and the DC values and GCA effective connection values with significant differences between the two groups were extracted,and the correlation between them and MMSE and MoCA scores was analyzed.Results:Compared with the HC group,the DC values of the left inferior temporal gyrus,left hippocampus,left parahippocampal gyrus,left superior frontal gyrus,and left inferior frontal gyrus were increased,while the DC values of the right supplementary motor area,right Cerebelum Crus1 and Crus2 areas were decreased in ACMP group(P<0.05,FWE corrected).The bidirectional effective connectivity effect between the left inferior temporal gyrus and the bilateral precuneus,right inferior temporal gyrus and left paracentral lobule was abnormal.In addition,the effective connectivity from the left inferior temporal gyrus to the right superior parietal gyrus and bilateral Cerebelum_Crus1 was enhanced,and the effective connection to bilateral cingulate gyrus,left superior frontal gyrus and left middle frontal gyrus was weakened,while the effective connectivity from the right paracentral lobule to the left inferior temporal gyrus was weakened(P<0.05,GRF corrected).Correlation analysis showed that the changes of effective network connectivity was correlated with MoCA and MMSE scores(P<0.05).Conclusion:ACMP patients show abnormal degree centrality in the brain network,mainly have effective functional connectivity abnormalities in the default Mode network(DMN),Central executive network(CEN),and Sensorimotor network(SMN),indicating that patients may have whole brain multi-functional network damage in the early stage.
作者
邓雪梅
李婷
翟昭华
DENG Xue-mei;LI Ting;ZHAI Zhao-hua(Medical Imaging Key Laboratory of Sichuan Provincial,Department of Radiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000;Department of Radiology,the Second People's Hospital of Neijiang,Neijiang 641000,Sichuan,China)
出处
《川北医学院学报》
CAS
2024年第4期538-543,共6页
Journal of North Sichuan Medical College
基金
川北医学院校级科研发展计划项目(CBY21-QA43)。
关键词
急性一氧化碳中毒
度中心度
格兰杰因果分析
有效连接
Acute carbon monoxide poisoning
Degree centrality
Granger causality analysis
Effective connection
