摘要
目的:探讨依达拉奉右莰醇与丁苯酞联合治疗对急性脑梗死(ACI)患者神经生长因子、血液流变学的影响。方法:按照随机数字表法将2021年2月至2023年6月邵武市立医院收治的84例ACI患者分为观察组和对照组,分别为42例。对照组采用丁苯酞治疗,观察组在对照组基础上加用依达拉奉右莰醇治疗。比较两组患者临床疗效、不良反应发生情况以及治疗前后神经生长因子水平、血液流变学指标、生活质量。结果:两组比较,观察组患者临床总有效率较高,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。治疗14 d后,两组比较,观察组患者内皮素–1水平、血液流变学指标均较低,血管内皮生长因子、一氧化氮水平、各项健康调查量表(SF–36)评分均较高,差异具有统计学意义(P<0.05)。结论:应用丁苯酞联合依达拉奉右莰醇治疗,可促进ACI患者神经生长因子水平改善,调节血液流变学,提升神经功能,且安全可靠。
Objective To investigate the effects of edaravone dexborneol combined with butylphthalide on nerve growth factor and hemorheology in patients with acute cerebral infarction(ACI).Methods According to random number table method,84 patients with ACI admitted to Shaowu Municipal Hospital from February 2021 to June 2023 were divided into a control group and an observation group,with 42 cases in each group.The control group was treated with butylphthalide,and the observation group was treated with edaravone dexborneol.The clinical efficacy,occurrence of adverse reactions,nerve growth factor level,hemorheology index and quality of life before and after treatment were compared between the two groups.Results Compared with the control group,the total clinical effective rate of the observation group was higher,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 14 days of treatment,compared with the control group,the levels of endothelin-1 and hemorheology indexes in the observation group were lower,and the level of vascular endothelial growth factor,nitric oxide and scores of 36-item short form health survey(SF-36)were higher in the observation group,with statistical significance(P<0.05).Conclusion Treatment with butylphthalide combined with edaravone dexborneol can improve the levels of nerve growth factor,regulate hemorheology,and enhance nerve function in ACI patients,and is safe and reliable.
作者
章高华
俞广权
ZHANG Gaohua;YU Guangquan(Shaowu Municipal Hospital,Fujian Shaowu 354000)
出处
《深圳中西医结合杂志》
2023年第24期121-124,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
急性脑梗死
丁苯酞
依达拉奉右莰醇
Acute cerebral infarction
Butylphthalide
Edaravone dexborneol
