摘要
宫颈癌是女性最常见的生殖系统恶性肿瘤,高危型人乳头状瘤病毒持续感染是其主要致病因素。传统治疗方法包括手术、放疗和化疗,但对晚期宫颈癌患者的预后并不理想。近年来治疗性疫苗、免疫检查点抑制剂和过继性T细胞疗法等免疫治疗在宫颈癌中应用广泛,显著改善了患者的生存期。本文将对免疫治疗在局部晚期宫颈癌中的临床研究及相关进展进行综述。
Cervical cancer is the most common reproductive system malignancy in women.Its primary cause is persistent infection with highrisk human papillomavirus.Traditional treatment methods include surgery,radiotherapy,and chemotherapy,but the prognosis for advanced cervical cancer remains dismal.In recent years,therapeutic vaccines,immune checkpoint inhibitors,adoptive T cell therapy,and other immunotherapies have been widely used in cervical cancer,notably improving patient survival.This article reviews clinical trials and recent advances in immunotherapy for in locally advanced cervical cancer(LACC).
作者
刘春艳(综述)
刘文欣(审校)
Chunyan Liu;Wenxin Liu(Department of Gynecological Oncology,Tianjin Medical University Cancer Institute&Hospital,National Clinical Research Center for Cancer,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin’s Clinical Research Center for Cancer,Tianjin 300060,China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2023年第24期1280-1283,共4页
Chinese Journal of Clinical Oncology
关键词
免疫治疗
同步放化疗
新辅助治疗
局部晚期宫颈癌
immunotherapy
concurrent chemoradiotherapy
neoadjuvant therapy
locally adjuvant cervical cancer(LACC)
