摘要
目的:观察盐酸西替利嗪滴剂联合丙酸氟替卡松吸入气雾剂治疗过敏性鼻炎(AR)合并支气管哮喘(BA)患儿的疗效及安全性。方法:选取2020年1月-2022年6月我院收治的AR合并BA患儿84例,按随机数表法分为联合组与对照组各42例。对照组给予丙酸氟替卡松吸入气雾剂吸入治疗,联合组则采用盐酸西替利嗪滴剂联合丙酸氟替卡松吸入气雾剂治疗,比较两组患儿治疗前后AR和BA严重程度评分、肺功能指标[第1秒用力呼气量(FEV1)、呼气流速(PEF)、用力肺活量(FVC)]、血清酶学[可溶性细胞间粘附分子-1(sICAM-1)、可溶性血管细胞间粘附分子-1(sVCAM-1)、白细胞介素-4(IL-4)、IL-10]、血清淀粉样蛋白(SAA)水平及不良反应发生情况。结果:治疗后,联合组AR与BA严重程度评分低于对照组,FEV1、PEF及FVC水平高于对照组(P均<0.05);两组sICAM-1、sVCAM-1、IL-4、IL-10及SAA水平均下降,且联合组均低于对照组(P均<0.05);两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论:采用盐酸西替利嗪滴剂联合丙酸氟替卡松吸入气雾剂治疗AR合并BA患儿,能显著减轻临床症状,有效改善肺功能,调节血清酶学指标与SAA水平,且不会增加不良反应的发生。
Objective:To observe the efficacy and safety of cetirizine hydrochloride drops combined with fluticasone propionate inhalation in the treatment of allergic rhinitis(AR) complicated with bronchial asthma(BA) in children.Methods:A total of 84 children with AR complicated with BA admitted into our hospital from Jan.2020 and Jun.2022 were enrolled to be divided into the combination group and control group via the random number table method,with 42 cases in each group.The control group was treated with fluticasone propionate inhalation,while the combination group was additionally given cetirizine hydrochloride drops combined with fluticasone propionate inhalation.The scores of AR and BA severity,pulmonary function indicators such as forced expiratory volume in one second(FEV1),peak expiratory flow(PEF),forced vital capacity(FVC),serum enzymes such as soluble intercellular adhesion molecule-1(sICAM-1),soluble vascular intercellular adhesion molecule-1(sVCAM-1),interleukin-4(IL-4) and IL-10,serum amyloid protein A(SAA) before and after treatment and occurrence of adverse drug reactions were compared between two groups.Results:After treatment,scores of AR and BA severity in combination group were significantly lower than those in control group(P<0.05),while levels of FEV1,PEF and FVC were significantly higher than those in control group(P<0.05).After treatment,levels of sICAM-1,sVCAM-1,IL-4,IL-10 and SAA decreased in both groups,and the combination group was lower than control group(P<0.05).There was no significant difference in the incidence of adverse drug reactions between two groups(P>0.05).Conclusion:Cetirizine hydrochloride drops combined with fluticasone propionate inhalation can significantly relieve clinical symptoms,effectively improve pulmonary function,regulate serum zymetology indicators and SAA in children with AR complicated with BA,which will not increase the incidence of adverse drug reactions.
作者
黄萌萌
董亮亮
王红梅
Huang Mengmeng;Dong Liangliang;Wang Hongmei(Liaocheng Second People’s Hospital,Shandong Liaocheng 252600,China)
出处
《儿科药学杂志》
CAS
2024年第2期28-31,共4页
Journal of Pediatric Pharmacy
