摘要
目的分析冠状动脉粥样硬化性心脏病(简称冠心病)心律失常患者应用美托洛尔与他汀类药物联合治疗对症状的改善效果。方法本研究随机选取2020年1月—2022年12月福建省永安市立医院收治的80例冠心病心律失常患者作为研究对象,根据随机抽签方法划分为对照组、观察组,每组40例。对照组使用美托洛尔单一用药治疗,观察组在此基础上增加他汀类药物治疗,比较两组患者临床疗效、期前收缩、心功能、不良反应。结果观察组总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(χ^(2)=4.114,P<0.05)。治疗后,观察组室性期前收缩、房性期前收缩均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组左心室收缩末期内径低于对照组,左心室舒张末期容量、左心室收缩末期容量、左心室射血分数均高于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论通过应用美托洛尔与他汀类药物联合治疗的方式,有助于提升冠心病心律失常患者临床疗效,改善临床指标,该方法在增加一种治疗药物的基础上,没有明显增加不良反应,值得普及。
Objective To analyze the improvement effect of symptoms in patients with coronary atherosclerotic heart disease(CHD)arrhythmia by the application of Metoprolol and statin combination therapy.Methods In this study,80 patients with coronary heart disease arrhythmia admitted to Yong'an Municipal Hospital of Fujian Province from Janu⁃ary 2020 to December 2022 were randomly selected as research objects and divided into control group and observa⁃tion group according to random drawing method,with 40 cases in each group.The control group was treated with Meto⁃prolol monotherapy,and the observation group was treated with Statins on this basis.The clinical efficacy,precontraction,cardiac function and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.00%,higher than that of the control group(80.00%),and the difference was statis⁃tically significant(χ^(2)=4.114,P<0.05).After treatment,the pre-ventricular contraction and pre-atrial contraction in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular end-systolic diameter in the observation group was lower than that in the control group,and the left ventricular end-diastolic volume,left ventricular end-systolic volume and left ventricular ejection fraction were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Through the application of combined treatment of Metoprolol and Sstatins,it helps to enhance the clinical efficacy of patients with coronary artery disease arrhythmia and improve their clinical indexes,and this method is worth popularizing as there is no obvious increase in adverse reactions on the basis of adding one therapeu⁃tic drug.
作者
陈毅洁
丁斌
林芳香
CHEN Yijie;DING Bin;LIN Fangxiang(Department of Cardiovascular Medicine,Yong'an Municipal Hospital,Yong'an,Fujian Province,366000 China)
出处
《中外医疗》
2023年第30期91-94,共4页
China & Foreign Medical Treatment
关键词
冠心病
心律失常
美托洛尔
他汀类药物
临床疗效
Coronary artery disease
Arrhythmia
Metoprolol
Statins
Clinical efficacy
