摘要
目的:研究阿托伐他汀的作用机理及其联合美托洛尔在心肌梗死(MI)合并室性心律失常(VA)患者治疗中的应用价值。方法:将某院收治的86例MI合并VA患者随机分为C组和C+A组各43例,C组在常规治疗的基础上实施单纯的美托洛尔治疗,C+A组在常规治疗的基础上实施美托洛尔+阿托伐他汀治疗,对比两组患者的临床疗效,并于治疗前后分别检测血清心肌损伤指标[肌钙蛋白T(cTnT)、肌酸激酶(CK)]和血管内皮功能指标[同型半胱氨酸(Hcy)、内皮素(ET)、一氧化氮(NO)]。结果:C+A组临床干预总有效率为88.37%,高于C组的74.42%(P<0.05);治疗后,C+A组患者血清cTnT、CK均低于C组(P<0.05),血清Hcy、ET均低于C组(P<0.05),血清NO高于C组(P<0.05)。结论:在美托洛尔治疗的基础上联合应用阿托伐他汀能有效减轻MI合并VA患者的心肌损伤程度,改善患者血管内皮功能,提高整体疗效。
Objective:To study the mechanism of atorvastatin and its application value of combined with metoprolol in the treatment of patients with myocardial infarction(MI)complicated with ventricular arrhythmia(VA).Methods:86 patients with MI complicated with VA admitted to a hospital were randomly divided into C group(n=43)and C+A group(n=43),who were treated with metoprolol alone and metoprolol+atorvastatin on the basis of conventional treatment.The clinical efficacy of the two groups were compared,and serum myocardial injury indexes cTnT,CK and vascular endothelial function indexes Hcy,ET,NO_(2)were detected before and after treatment.Results:The total effective rate of clinical intervention in C+A group was 88.37%,higher than that in C group(74.42%,P<0.05).After treatment,serum cTnT and CK in C+A group were lower than those in C group(P<0.05),serum Hcy and ET were lower than those in C group(P<0.05),and serum NO_(2)was higher than those in C group(P<0.05).Conclusion:Combined application of atorvastatin on the basis of metoprolol therapy can effectively reduce the degree of myocardial injury in MI patients complicated with VA,improve the vascular endothelial function of patients,and improve the overall efficacy.
作者
贾苗云
Jia Miaoyun(Luoyang Zhuge Siqin Hospital,Luoyang 471900)
出处
《数理医药学杂志》
CAS
2022年第5期729-731,共3页
Journal of Mathematical Medicine
关键词
心肌梗死
室性心律失常
阿托伐他汀
美托洛尔
心肌损伤
血管内皮功能
myocardial infarction
ventricular arrhythmia
atorvastatin
metoprolol
myocardial injury
vascular endothelial function
