摘要
为评估化妆品原料光甘草定的安全性,为光甘草定在化妆品中的应用提供数据支持,按照《化妆品安全评估技术导则》(2021年版)对光甘草定用于化妆品的安全性进行了评估。结果显示,光甘草定在质量分数0.05%用量下的皮肤刺激性、眼刺激性、光毒性、光敏性、致敏性、遗传毒性、亚慢性毒性等风险较低,当使用的质量分数不高于0.05%时,用于无吸入暴露风险的驻留类面部、体用产品、唇膏及各种淋洗类产品中,应用风险可接受。在使用过程中应参考《中国药典》对原料中可能含有的有机溶剂残留进行质量控制,并在标签上增加必要的警示语,避免同时使用多种含有光甘草定的化妆品。
In order to evaluate the safety of glabridin as cosmetic ingredient,support for its application in cosmetics,the safety assessment of glabridin when used in cosmetics was taken,in accordance with the Technical Guidelines for Safety Assessment of Cosmetics(2021).The results of evaluation show that,risks of skin irritation,eye irritation,phototoxicity,photosensitivity,sensitization,genotoxicity,and subchronic toxicity are low at the glabridin dosage of 0.05%(in mass fraction).When the mass concentration does not exceed 0.05%,the application risk is acceptable,when used in leave-in facial,body products,lipsticks and various rinse-off products that do not pose a risk of inhalation exposure.It’s necessary to control the residual organic solvent that may be contained in glabridin according to Pharmacopoeia of the Peoples Republic of China,add necessary warning words on the label,and avoid to simultaneously use various cosmetics containing glabridin.
作者
王亚峰
郭沈涛
邓淑鸿
李适炜
赵江华
WANG Yafeng;GUO Shentao;DENG Shuhong;LI Shiwei;ZHAO Jianghua(Guangdong Youzhi Testing Technology Co.,Ltd.,Guangzhou 510000,Guangdong,China;Guangdong Bawei Biotechnology Corporation,Guangzhou 510000,Guangdong,China)
出处
《香料香精化妆品》
CAS
2023年第6期96-101,共6页
Flavour Fragrance Cosmetics
关键词
光甘草定
毒理
安全性评估
glabridin
toxicology
safety assessment
