摘要
[目的]研究氢化胡椒碱对光甘草定软膏体外透皮作用的影响。[方法]通过改良Franz垂直扩散池考察光甘草定的透皮吸收性能,以高效液相色谱法测定光甘草定含量,以考察氢化胡椒碱、氮酮、冰片对光甘草定透皮吸收的影响。[结果]不同促渗剂对光甘草定累积透过量顺序为0.04%氢化胡椒碱组>0.03%氢化胡椒碱组>0.02%氢化胡椒碱组>5%氮酮组>3%氮酮组>2%冰片组>单体组,0.04%氢化胡椒碱组的24 h的累积渗透量最大,为26.51μg/cm2,其促渗速率的增渗倍数最大,较单体组提高了5.03倍。[结论]不同的促渗剂对光甘草定均有促渗作用,并且0.04%氢化胡椒碱为透皮促渗剂对光甘草定体外透皮吸收效果最佳,可促进光甘草定快速有效的渗透。
[Objective] To investigate the effect of Tetrahydropiperine on transdermal of Glabridin in ointment. [Methods] Franz vertical diffusion cell was adopted to investigate transdermal performance of glabridin and observe the effect of Tetrahydropiperine（THP）, azone,borneol on transdermal permeation of Glabridin. [Results] Effect of enhancers on Glabridin was ranked as follows： 0.04%THP 〉 0.03%THP 〉 0.02%THP 〉 5% azone 〉 3%azone 〉 2%borneol. When the content of THP was 0.04%, the cumulative permeation of Glabridin was the highest, up to 26.51 μg/cm2. The penetration rate amount with 0.04%THP was 5.03 times than which no permeation enhancer.[Conclusion] These different permeation enhancer have the effect of Glabridin, Glabridin can be permeated quickly and efficiently.
出处
《天津中医药》
CAS
2016年第3期177-181,共5页
Tianjin Journal of Traditional Chinese Medicine
基金
西青区科技型中小企业发展专项资金项目(XQKH2013-011)
天津中医药大学第四届大学生科技创新基金项目(CXJJ2013ALL)
关键词
光甘草定
促渗剂
透皮吸收
氢化胡椒碱
Glabridin
penetration enhancers
transdermal
Tetrahydropiperine
