摘要
目的研究血清炎症因子等因素对老年(≥60岁)股骨粗隆间骨折患者术后死亡率的影响。方法该研究共收纳了来自2家医院的181例老年股骨粗隆间骨折患者。记录并分析患者的性别、年龄、BMI、住院时间、美国麻醉师协会(ASA)评分、吸烟和饮酒习惯、是否和子女一起居住、Hb以及6项外周血炎性细胞因子浓度。最后根据研究结果设计死亡风险预测模型。结果高龄、高ASA评分、与子女分居、高IL-6和高TNF-α浓度是老年人股骨粗隆间骨折术后死亡的重要危险因素。其他因素的变化对骨折术后死亡率无显著影响。基于上述发现,构建的预测模型可以更好地评估股骨粗隆间骨折术后死亡的风险,预防其发生。结论高龄、高ASA评分、与子女分居的老年股骨粗隆间骨折患者术后死亡率高,术后炎症因子水平过高是患者死亡的高危因素。
Objective To investigate the influence of serum inflammatory cytokines and other factors on the postoperative mortality of elderly patients(≥60 years old)with femoral intertrochanteric fracture.Methods 181 elderly patients with intertrochanteric fracture from two hospitals were enrolled in this study.The patients'gender,age,BMI,length of stay,American Association of Anesthesiologists(ASA)score,smoking and drinking habits,living with offspring or not,concentration of Hb and 6 inflammatory cytokines in peripheral blood were recorded and analyzed.The death risk prediction model was designed according to the results.Results Old age,high ASA score,separation from offspring,high IL-6 and TNF-αconcentration were pivotal risks of death after intertrochanteric fracture surgery in the elderly.Variations of other factors have no significant influence on the mortality after fracture surgery.Based on the above findings,the prediction model could assess the risk of death after intertrochanteric fracture surgery and prevent its occurrence.Conclusion The mortality of elderly patients with intertrochanteric fracture is notably higher when they live separately from their children and have high ASA scores.Additionally,higher level of postoperative inflammatory factors indicates increased risk for death.
作者
李苏成
姜为民
王喜安
钱佳乐
潘明铭
李人杰
季逸超
蒋东冬
陆敏华
LI Su-cheng;JIANG Wei-min;WANG Xi-an;QIAN Jia-le;PAN Ming-ming;LI Ren-jie;JI Yi-chao;JIANG Dong-dong;LU Min-hua(Department of Orthopedics,Suzhou Dushuhu Public Hospital,Suzhou,Jiangsu,215125,China;Department of Orthopedics,Nanjing No.1 People's Hospital,Nanjing,Jiangsu,210012,China)
出处
《中国血液流变学杂志》
CAS
2023年第1期89-95,共7页
Chinese Journal of Hemorheology
关键词
炎症因子
股骨粗隆间骨折
死亡率
老年人
inflammatory cytokines
intertrochanteric fracture
mortality
elderly patients
