摘要
目的分析超敏C反应蛋白(hs-CRP)/白蛋白(Alb)、活化转录因子4(ATF4)对急性心肌梗死(AMI)患者新发心房颤动的预测价值。方法选取2020年1月至2022年9月收治的398例AMI患者为观察组,并选取同期健康体检者398例为健康组。两组均采集外周血,检测血清hs-CRP、Alb、ATF4水平,计算hs-CRP/Alb。观察组根据住院期间是否新发心房颤动分为新发心房颤动患者和无新发心房颤动患者。通过电子病历系统收集入选患者资料,根据最邻近匹配法对新发心房颤动患者和无新发心房颤动患者进行1:1匹配,Logistic回归模型计算评分值。对纳入的因素进行单因素和多因素Logistic回归分析,筛选出新发心房颤动的预测因素,绘制受试者工作特征曲线(ROC)分析hs-CRP/Alb、ATF4对AMI患者新发心房颤动的预测价值。结果观察组hs-CRP/Alb、ATF4水平高于健康组,差异有统计学意义(P<0.05)。二元Logistic多因素回归分析结果显示,入院时心率、肌钙蛋白Ⅰ、左心房内径、hs-CRP/Alb、ATF4是AMI患者新发心房颤动的独立影响因素(P<0.05);hs-CRP/Alb、ATF4联合预测新发心房颤动的曲线下面积(AUC)值高于单独评估的AUC值(P<0.05)。结论AMI患者hs-CRP/Alb、ATF4可应用于预测新发心房颤动,二者联合对AMI患者新发心房颤动的预测效能更佳。
Objective To analyze the predictive value of hypersensitive C-reactive protein(hs-CRP)/albumin(Alb)and activated transcription factor 4(ATF4)for new atrial fibrillation in patients with acute myocardial infarction(AMI).Methods A total of 398 AMI patients diagnosed and treated in our hospital from January 2020 to September 2022 were selected as the observation group,and 398 healthy people who underwent physical examination during the same period were selected as the health group health group.The observation group was divided into patients with new-onset atrial fibrillation and patients without new-onset atrial fibrillation according to whether new-onset atrial fibrillation occurred during hospitalization.The data of the selected patients were collected through the electronic medical record system.The patients with new atrial fibrillation and those without new atrial fibrillation were matched 1:1 according to the nearest neighbor matching method,and the score value was calculated by Logistic regression model.Univariate and multivariate Logistic regression analysis were used to screen the predictors of new-onset atrial fibrillation.Receiver operating characteristic curve(ROC)was drawn to analyze the predictive value of hs-CRP/Alb and ATF4 for new-onset atrial fibrillation in AMI patients.Results The levels of hs-CRP/Alb and ATF4 in the observation group were higher than those in the healthy group,and the difference was statistically significant(P<0.05).Binary Logistic multivariate regression analysis showed that heart rate,troponinⅠ,left atrial diameter,hs-CRP/Alb and ATF4 on admission were independent influencing factors of new atrial fibrillation in AMI patients(P<0.05).The area under the curve value of hs-CRP/Alb and ATF4 combined predicted new atrial fibrillation was higher than that of single evaluation(P<0.05).Conclusion hs-CRP/Alb and ATF4 can be used to predict new-onset atrial fibrillation in AMI patients.The combination of hS-CRP/ALB and ATF4 has a better predictive efficiency for new-onset atrial fibrillation in AMI patients.
作者
贾慧宇
刘昊鹏
李凯
韩培天
李术伟
徐俊华
JIA Hui-yu;LIU Hao-peng;LI Kai;HAN Pei-tian;LI Shu-wei;XU Jun-hua(Department of Clinical laboratory,The Second Affiliated Hospital of Hebei North University;不详)
出处
《创伤与急危重病医学》
2023年第2期104-109,共6页
Trauma and Critical Care Medicine
基金
河北省医学科学研究课题(20200498)。
