摘要
目的探讨益脑通络方联合刺络放血治疗缺血性中风患者的临床疗效。方法选取2019年10月—2021年6月期间安阳市中医院脑病一科收治的缺血性中风患者100例,按照入院先后顺序分为对照组和观察组,每组各50例。对照组采用益脑通络方治疗,观察组采用益脑通络方联合刺络放血治疗。治疗2周后,观察比较两组患者临床疗效,治疗前后中医证候积分、神经功能缺损评分[美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分]、脑血管血流动力学指标(大脑中动脉血流速度、基底动脉血流速度)、神经生化标志物指标[神经元特异性烯醇化酶(Neuron-specific Enolase,NSE)、中枢神经特异蛋白(Soluble Protein-100β,S100β)]。结果治疗后两组患者中医证候积分及神经功能缺损评分均较治疗前降低,差异有统计学意义(P<0.05);且观察组中医证候积分及神经功能缺损评分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者脑血管血流动力学指标较治疗前升高,差异有统计学意义(P<0.05);且观察组大脑中动脉血流速度、基底动脉血流速度明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清NSE、S100β水平较对照组降低,差异有统计学意义(P<0.05);且观察组血清NSE、S100β水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组总有效率92.00%(46/50)高于对照组74.00%(37/50),差异有统计学意义(P<0.05)。结论益脑通络方联合刺络放血能提高缺血性中风治疗效果,改善临床症状及脑血管血流动力学,减轻神经缺损程度,调节血清NSE、S100β水平。
Objective To explore the curative effect of Yinaotongluo Prescription combined with puncture and blood-letting in the treatment of ischemic stroke.Methods Subjects of 100 patients with ischemic stroke admitted to Encephalopathy in Anyang Traditional Chinese Medicine Hospital from October 2019 to June 2021 were include and divided into control group and observation group according to the order of admission.The 50 cases in control group were treated with Yicnaotongluo Prescription,and the other 50 cases in observation group were treated with Yicnaotongluo Prescription combined with puncture and blood-letting.Both groups were treated for 2 weeks.TCM syndrome score,neurological deficit score,cerebrovascular hemodynamic index and neurobiochemical markers were compared between the two groups before and after treatment,and the clinical efficacy was compared.Results After treatment,the scores of both TCM syndrome and neurological deficit were lower than those before treatment,with statiatical significance(P<0.05).The TCM syndrome score and neurological deficit score of the observation group were significantly lower than those of the control group(P<0.05).After treatment,cerebral vascular hemodynamics indexes were higher than that before treatment,with statistical significance(P<0.05).And the blood flow velocity of the middle cerebral artery and basilar artery in observation group was significantly higher than that in control group(P<0.05).The serum levels of NSE and S100βin observation group were significantly lower than those in control group after treatment(P<0.05).The total effective rate of observation group(92.00%,45/50)was significantly higher than that of control group(74.00%,37/50)(P<0.05).Conclusion YicnaotongluoPrescription combined with puncture and blood-letting can improve the therapeutic effect of ischemic stroke,improve clinical symptoms and cerebrovascular hemodynamics,reduce the degree of nerve defect,and regulate the levels of serum NSE and S100β.
作者
张慧永
窦晓清
宋文俊
张国妮
ZHANG Hui-yong;DOU Xiao-qing;SONG Wen-jun;ZHANG Guo-ni(Department of Encephalopathy,Anyang Hospital of Traditional Chinese Medicine,Henan Anyang 455000;Department of Otolaryngology,Anyang Hospital of Traditional Chinese Medicine,Henan Anyang 455000)
出处
《世界中西医结合杂志》
2023年第2期383-386,391,共5页
World Journal of Integrated Traditional and Western Medicine
基金
河南省中医药科学研究专项课题(2015ZY03023)。
关键词
缺血性中风
益脑通络方
刺络放血
Ischemic Stroke
Yinao Tongluo Prescription
Puncture and Blood-letting
