摘要
【目的】观察纳洛酮治疗脑梗死的量效关系,探讨纳洛酮治疗脑梗死的最佳剂量。【方法】抽取 100例脑梗死患者随机分配为1、2、3、4组,每组25例,分别用1.6mg、2.8mg、3.6mg、5.2mg剂量的纳洛酮 治疗,疗程15d,观察临床疗效,并做出量效关系曲线。【结果】结果表明,用1.6mg纳洛酮治疗基本无效;2.8 mg纳洛酮治疗稍有好转,量效关系曲线处于上升阶段;3.6mg纳洛酮治疗有效,量效关系曲线处于高速上 升阶段;3.6～5.2mg纳洛酮治疗明显好转,但从量效曲线上看上升趋势已不明显。【结论】结合量效关系曲 线,纳洛酮治疗脑梗死最佳剂量为3.6～5.2mg。
ObjectiveTo observe the dose-effect relationship of naloxone and explore its best dosage for the treatment of cerebral infarction (CI).One hundred patients with CI were randomly divided into I to IV groups. Twenty-five patients were included for each group, they were treated with different dosages of naloxone:1.6 mg, 2.8 mg, 3.6 mg, 5.2 mg for 15 days, respectively. The clinical therapeutic efficacy in each group was observed and the curve of dose-effect relationship(CDER) was plotted.Study with random assignment showed that the dosage of 1.6mg naloxone was basically ineffective ; the symptoms got improved slightly with the dosage of 2.8 mg naloxone, its CDER was at the ascending stage; 3.6 mg naloxone exhibited effective results, with its CDER at rapidly ascending stage ; symptoms were markedly improved with the dosage of 3.6 mg to 5.2 mg naloxone, but the ascending tendency of curve became less distinct.[Conclusion]According to analysis of CDER, the best dosage of naloxone to treat CI is 3.6 ~ 5.2 mg.
出处
《医学临床研究》
CAS
2004年第9期1015-1017,共3页
Journal of Clinical Research
