摘要
目的 分析总胆固醇/高密度脂蛋白胆固醇比值(TC/HDL-C)联合中性粒细胞多肽1-3(HNP1-3)、脂蛋白a检测在冠心病临床诊断中的应用。方法 选取2018年3月至2021年3月于丰都县人民医院治疗的105例冠心病患者的临床资料,将其设为研究组,另选取87名本院同时间段进行健康体检者作为对照组。比较研究组与对照组、研究组不同病变程度患者TC/HDL-C、HNP1-3、脂蛋白a水平,采用工作特征曲线(ROC)分析TC/HDL-C联合HNP1-3、脂蛋白a检测对冠心病的诊断价值。结果 研究组TC/HDL-C、HNP1-3、脂蛋白a水平均高于对照组,两组差异具有统计学意义(P<0.05)。TC/HDL-C、HNP1-3、脂蛋白a水平:重度病变组>中度病变组>轻度病变组,组间差异具有统计学意义(P<0.05)。ROC曲线显示:TC/HDL-C、HNP1-3、脂蛋白a单独检测及三者联合检测AUC分别为0.879、0.881、0.887、0.925,其中以三者联合检测AUC值最大(P<0.05)。结论 TC/HDL-C联合HNP1-3、脂蛋白a检测可有效诊断冠心病,为临床病情诊断提供参考。
Objective To analyze the application of total cholesterol/high density lipoprotein cholesterol ratio(TC/HDL-C)combined with detection of neutrophil polypeptide 1-3(HNP1-3)and lipoprotein A in the clinical diagnosis of coronary heart disease. Methods The clinical data of 105 patients with coronary heart disease treated in Fengdu County People’s Hospital from March 2018 to March 2021 were selected and set as the study group,and 87 patients who underwent physical examination in the hospital at the same time were selected as the control group. The levels of TC/HDL-C,HNP1-3 and lipoprotein A were compared between the study group and the control group,and patients with different lesion degrees in the study group,and the operating characteristic curve(ROC)was used to analyze the detection of TC/HDL-C combined with HNP1-3,lipoprotein A diagnostic value for coronary heart disease. Results The levels of TC/HDL-C,HNP1-3 and lipoprotein A in the study group were higher than those in the control group,and the difference between the two groups was statistically significant(P<0.05). The levels of TC/HDL-C,HNP1-3,and lipoprotein A:severe disease group >moderate disease group >mild disease group,the difference between the groups was statistically significant(P<0.05). The ROC curve showed that the AUCs of TC/HDL-C,HNP1-3,lipoprotein A alone and the three combined detection were 0.879,0.881,0.887,and 0.925,respectively,and the AUC value of the combined detection of the three was the largest(P<0.05). Conclusion TC/HDL-C combined with HNP1-3 and lipoprotein A detection can effectively diagnose coronary heart disease,and provide reference for clinical diagnosis.
作者
陈丽娟
周宇生
栾颖
张开忠
CHEN Lijuan;ZHOU Yusheng;LUAN Ying;ZHANG Kaizhong(Department of Cardiovascular Medicine,Fengdu County People's Hospital,Chongqing,China,400039)
出处
《分子诊断与治疗杂志》
2023年第2期261-264,共4页
Journal of Molecular Diagnostics and Therapy
