摘要
目的探讨锌制剂辅助益生菌对腹泻患儿肠道菌群平衡、肠屏障功能和免疫功能的影响。方法选取2018年03月至2020年11月在我院接收治疗的86例腹泻患儿,按照随机信封法分为2组,对照组(n=43例,接受双歧杆菌三联活菌散治疗),观察组(n=43例,接受双歧杆菌三联活菌散+葡萄糖酸锌颗粒治疗),比较2组治疗后肠道菌群、肠屏障功能以及免疫功能。结果治疗7d观察组菌群平衡情况好于对照组(P<0.05);治疗7d观察组内毒素、D-乳酸与二胺氧化酶水平低于对照组(P<0.05);治疗7d观察组免疫球蛋白M(Ig M)、免疫球蛋白G(IgG)与CD4/CD8水平高于对照组(P<0.05)。结论锌制剂辅助益生菌治疗小儿急性腹泻有助于调节患儿肠道菌群平衡、改善肠屏障功能及增强机体免疫功能,效果良好,临床可参考。
Objective To explore the effects of zinc preparation supplemented with probiotics on intestinal flora balance,intestinal barrier function and immune function in children with diarrhea.Methods 86 children with diarrhea who received treatment in the hospital from March 2018 to November 2020 were selected and divided into two groups according to the random envelope method,including control group(n=43,receiving bifidobacterium triple viable powder)and observation group(n=43,given bifidobacterium triple viable powder+zinc gluconate granules treatment).The intestinal flora,intestinal barrier function and immune function were compared between the two groups after treatment.Results The flora balance in observation group was better than that in control group after 7 days of treatment(P<0.05).The levels of endotoxin,D-lactic acid and diamine oxidase in observation group after 7 days of treatment were lower compared with those in control group(P<0.05).The levels of immunoglobulin M(Ig M),immunoglobulin G(Ig G)and CD4/CD8 were higher in observation group after 7 days of treatment(P<0.05).Conclusion Zinc preparation supplemented with probiotics in the treatment of acute infantile diarrhea can help to regulate the balance of intestinal flora,improve the intestinal barrier function and enhance the body’s immune function of children,and it has good effects and is worthy of clinical reference.
作者
田斌斌
郭小凤
申永霞
李婕
TIAN Bin-bin;GUO Xiao-feng;SHEN Yong-xia;LI Jie(Department of Emergency,Kaifeng Children's Hospital,Kaifeng 475000,Henan Province,China;Department of Neonatal,Kaifeng Children's Hospital,Kaifeng 475000,Henan Province,China;Department of Internal Medicine Outpatient,Kaifeng Children's Hospital,Kaifeng 475000,Henan Province,China)
出处
《罕少疾病杂志》
2023年第2期71-73,共3页
Journal of Rare and Uncommon Diseases
关键词
锌制剂
益生菌
小儿腹泻
肠道菌群
肠屏障功能
免疫功能
Zinc Preparation
Probiotics
Infantile Diarrhea
Intestinal Flora
Intestinal Barrier Function
Immune Function
