摘要
目的研究激素联合羟氯喹治疗免疫球蛋白A(IgA)肾病的效果。方法80例IgA肾病患者,采用随机分组的方式分为对照组和观察组,每组40例。对照组采用常规联合激素进行治疗,观察组采用激素联合羟氯喹进行治疗。对比两组治疗前后的实验室指标及治疗效果、治疗后的生活质量评分。结果治疗后,两组尿蛋白定量、尿血管细胞粘附分子、血清肌酐、肾小球滤过率、血清白蛋白均较治疗前改善,且观察组尿蛋白定量(0.8±0.2)g/24 h、尿血管细胞粘附分子(11.1±3.0)mg/L、血清肌酐(80.8±32.6)μmol/L低于对照组的(1.3±0.2)g/24 h、(23.8±3.1)mg/L、(93.1±21.2)μmol/L,肾小球滤过率(93.7±25.8)ml/min、血清白蛋白(48.4±6.5)g/L高于对照组的(81.3±21.4)ml/min、(42.1±5.4)g/L,差异均有统计学意义(P<0.05)。观察组治疗总有效率为97.50%,高于对照组的62.50%,差异有统计学意义(P<0.05)。观察组躯体功能评分(87.23±5.10)分、心理状态评分(84.51±5.43)分、生活水平评分(81.37±4.58)分、社会活动评分(86.97±3.58)分均高于对照组的(78.21±5.02)、(73.31±5.26)、(70.51±5.14)、(79.63±3.96)分,差异有统计学意义(P<0.05)。结论激素联合羟氯喹治疗IgA肾病的临床疗效较好,安全性高,能够提高患者的生活质量,值得大力推广应用。
Objective To study the effect of hormone combined with hydroxychloroquine on immunoglobulin A(IGA)nephropathy.Methods A total of 80 patients with IgA nephropathy were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with conventional methods combined with hormones,and the observation group was treated with hormones combined with hydroxychloroquine.The laboratory indexes before and after treatment,therapeutic effect,and quality of life scores after treatment were compared between the two groups.Results After treatment,the urinary protein quantification,urinary vascular cell adhesion molecule,serum creatinine,glomerular filtration rate and serum blood protein of both groups were improved compared with those of this group before treatment;the urinary protein(0.8±0.2)g/24 h,urinary vascular cell adhesion molecule(11.1±3.0)mg/L,and serum creatinine(80.8±32.6)μmol/L in the observation group were lower than(1.3±0.2)g/24 h,(23.8±3.1)mg/L,(93.1±21.2)μmol/L in the control group;the glomerular filtration rate(93.7±25.8)ml/min and serum blood protein(48.4±6.5)g/L in the observation group were higher than(81.3±21.4)ml/min and(42.1±5.4)g/L in the control group;all the differences were statistically significant(P<0.05).The total effective rate of the observation group was 97.50%,which was higher than 62.50%of the control group,and the difference was statistically significant(P<0.05).The physical function score(87.23±5.10)points,psychological state score(84.51±5.43)points,living standard score(81.37±4.58)points and social activity score(86.97±3.58)points in the observation group were higher than(78.21±5.02),(73.31±5.26),(70.51±5.14)and(79.63±3.96)points in the control group,and the differences were statistically significant(P<0.05).Conclusion Hormone combined with hydroxychloroquine has good clinical efficacy and high safety in the treatment of IgA nephropathy,and can improve the quality of life of patients,which is worthy of promotion and application.
作者
蔡增苗
CAI Zeng-miao(Department of Nephrology,Chifeng Hospital,Chifeng 024000,China)
出处
《中国现代药物应用》
2022年第15期112-115,共4页
Chinese Journal of Modern Drug Application
关键词
激素
羟氯喹
免疫球蛋白A肾病
治疗效果
Hormone
Hydroxychloroquine
Immunoglobulin A nephropathy
Therapeutic effect
