摘要
中医药在肝纤维化的治疗中具有独特的优势,但其中医理论的现代分子生物学机制仍未充分阐明。肝细胞是发挥肝脏合成代谢功能、调节铁代谢的重要场所,其调节铁蛋白储存和铁代谢的功能似与中医“肝藏血,主疏泄”理论相契合。本文采用“取象比类”法将肝细胞铁死亡与中医理论结合,提出肝纤维化中医基本病机“正虚血瘀”的现代分子生物学机制可能与铁过载诱导肝细胞铁死亡有关,为中医理论分子机制的阐明及创新中药研发提供新的思路。
Traditional Chinese medicine(TCM) has unique advantages in the treatment of hepatic fibrosis, but its molecular biological mechanism has not yet been completely elucidated. Hepatocyte is an important place to exert anabolic functions and regulate iron metabolism. Its function of regulating ferritin storage and iron metabolism seems to be consistent with the theory of liver concealing blood and dominating diffusion in TCM. The analogism method is used in this article to combine the hepatocyte ferroptosis with the theory of TCM, thus proposing that the molecular mechanism of "qi deficiency and blood stasis" of hepatic fibrosis in TCM may be related to iron overload-induced hepatocyte ferroptosis. This article may provide new ideas for the elucidation of the molecular mechanism of TCM theory and the development and innovation of TCM.
作者
肖准
杨芳明
代静慧
马素平
Xiao Zhun;Yang Fangming;Dai Jinghui;Ma Suping(The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;The First Clinical Medical College,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2022年第3期1090-1096,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会青年科学基金项目(82104772):基于KEAP1/NRF2/GPX4信号通路调控肝细胞铁死亡探讨桃红四物汤抗肝纤维化作用机制研究,负责人:肖准
河南中医药大学第一附属医院博士科研启动基金(2021BSJJ004):基于肝细胞铁死亡与肝星状细胞活化相互作用探讨桃红四物汤抗肝纤维化作用机制研究,负责人:肖准。
关键词
肝纤维化
正虚血瘀
取象比类
肝细胞
铁代谢
Hepatic fibrosis
Qi deficiency and blood stasis
Analogism
Hepatocyte
Iron metabolisms
