摘要
肝纤维化(Hepatic fibrosis,HF)是慢性肝损伤伴有肝脏损伤修复的病理生理过程。肝纤维化因各种致病因素导致肝内结缔组织异常增生,进一步发展为肝硬化,最终走向肝癌。许多学者已深入研究关于细胞因子介导多条信号通路诱导肝星状细胞及后续靶基因的活化,以逆转肝纤维化的发展。目前,肝纤维化的治疗主要包括病因治疗、抗纤维化药物治疗、原位移植、细胞疗法等,且不良反应较多。然而,中医的辨证论治、整体调护具有疗效佳、不良反应少的优势。研究单味中药、中药提取物及复方调控肝纤维化相关细胞因子,可为逆转肝纤维化提供丰富的药物选择。该文深入讨论了TGF-β、CTGF、IL-1、IL-17、IL-33、IL-37、TNF-α、PDGF等细胞因子在肝纤维化发展过程中的作用机制,以及中药和复方治疗肝纤维化的研究进展,旨在更好为肝纤维化的临床防治提供理论指导。
Hepatic fibrosis(HF)is a pathophysiological process of chronic liver injury with liver damage repair.Liver fibrosis causes abnormal proliferation of connective tissue in the liver due to various pathogenic factors,further develops into cirrhosis,and finally goes to liver cancer.Many scholars have intensively studied the activation of hepatic stellate cells and subsequent target genes by cytokine-mediated multiple signaling pathways to reverse the development of liver fibrosis.At present,the treatment of liver fibrosis mainly includes etiological treatment,anti-fibrotic drug treatment,orthotopic transplantation,cell therapy,etc.,and more adverse reactions.However,the dialectical treatment and overall adjustment of Chinese medicine have the advantages of good curative effect and few adverse reactions.However,the dialectical treatment and overall adjustment of Chinese medicine have the advantages of good curative effect and few adverse reactions.Studying single-flavor Chinese medicine,traditional Chinese medicine extract and compound regulating liver fibrosis-related cytokines can provide rich drug selection for reversing liver fibrosis.This article discusses in depth the mechanism of TGF-β,CTGF,IL-1,IL-17,IL-33,IL-37,TNF-α,PDGF and other cytokines in the development of liver fibrosis,as well as traditional Chinese medicine and compound treatment.The research progress of liver fibrosis aims to provide better theoretical guidance for the clinical prevention and treatment of liver fibrosis.
作者
白鹃
丁辉
施京红
梁佳
张婷
BAI Juan;DING Hui;SHI Jinghong;LIANG Jia;ZHANG Ting(Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China;Shaanxi Provincial Hospital of Chinese Medicine,Xi'an 710003,Shaanxi,China)
出处
《辽宁中医药大学学报》
CAS
2020年第1期158-162,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
陕西省教育厅科学研究项目(17JK0223).
关键词
肝纤维化
发病机制
细胞因子
中草药治疗
hepatic fibrosis
pathogenesis
cytokines
Chinese herbal medicine
