摘要
目的分析新型冠状病毒疫苗(新冠疫苗)加强针接种者血清新型冠状病毒(新冠)抗体IgG检测结果,为接种新冠疫苗加强针提供依据。方法已接种新冠疫苗的健康接种者314例,依据接种情况分为加强针组、两剂小于180天组、两剂大于180天组。加强针组为接种新冠疫苗加强针后1周~2月者,共205例;两剂小于180天组为完成两剂新冠疫苗接种后<180 d者,共49例;两剂大于180天组为完成两剂新冠疫苗接种后>180 d者,共60例。采用胶体金法测算三组接种者血清新冠抗体IgG阳性率。结果加强针组血清新冠抗体IgG阳性率为83.9%,两剂小于180天组血清新冠抗体IgG阳性率为18.4%,两剂大于180天组血清新冠抗体IgG阳性率为5.0%,两两比较,P均<0.05。加强针接种>1月者血清新冠抗体IgG阳性率为85.2%,加强针接种<1月者血清新冠抗体IgG阳性率为75.9%,两者相比,P>0.05。加强针组接种者中男性血清新冠抗体IgG阳性率为85.1%,女性血清新冠抗体IgG阳性率为82.4%,两者相比,P>0.05。加强针组接种者中18~50岁者血清新冠抗体IgG阳性率为86.0%,>50岁者血清新冠抗体IgG阳性率为58.3%,两者相比,P<0.05。结论与接种两剂新冠疫苗相比,接种新冠疫苗加强针可显著提升新冠抗体IgG阳性率,免疫保护作用更强。接种新冠疫苗加强针后,年龄>50岁者接种新冠疫苗加强针后新冠抗体IgG阳性率低于18~50岁者。
Objective To analyze IgG test results of serum SARS-CoV-2 antibody in people after booster vaccinations against SARS-CoV-2,and to provide a basis for the booster vaccination.Methods There were 314 healthy individuals who had been vaccinated with the COVID-19 vaccine.Depending on their inoculation situation,they were divided into three groups:the booster injection group(1 week to 2 months after booster vaccination)of 205 cases,<180 days after two doses group(<180 days after two doses of COVID-19 vaccine)of 49 cases,and>180 days after two doses group(>180 days after two doses of COVID-19 vaccine)of 60 cases.The positive rate of IgG in serum of the three groups was measured using the colloidal gold method.Results The serum COVID-19 antibody IgG positive rates were 83.9%in the booster injection group,18.4%in the<180 days after two doses group,and 5.0%in the>180 days after two doses group,with statistically significant difference between any two groups(all P<0.05).In the booster injection group,the serum COVID-19 antibody IgG positive rate was 85.2%in people who received a booster injection more than a month,while those who received a booster injection less than a month had a positive rate of 75.9%,and there was no significant difference between these two groups(P>0.05).In the booster injection group,the positive rates of serum COVID-19 antibody IgG were 85.1%in males and 82.4%in females,with no significant difference(P>0.05).In the booster injection group,people at the age of 18 and 50 had a positive serum COVID-19 antibody IgG rate of 86.0%,while those over 50 had a positive rate of 58.3%,and there was significant difference between them(P<0.05).Conclusions Compared with two injections of the COVID-19 vaccine,the booster injection can significantly increase the positive rate of the antibody IgG of COVID-19,which results in a stronger immune response.There is a lower IgG positive rate of COVID-19 antibodies in those aged over 50 years following the booster dose of COVID-19 vaccine than in those aged 18-50 years.
作者
张雪梅
孙成栋
刘佳
王燕
白鹭
童晶晶
尹海涛
ZHANG Xuemei;SUN Chengdong;LIU Jia;WANG Yan;BAI Lu;TONG Jingjing;YIN Haitao(Department of Infectious Diseases,Beijing Jishuitan Hospital,Beijing 100069,China;不详)
出处
《山东医药》
CAS
2022年第21期26-29,共4页
Shandong Medical Journal
基金
吴阶平医学基金会临床科研专项资助基金(320.6750.19089-98)。
