摘要
目的了解人参、甘草、地黄、杜仲、连翘、玫瑰花6种药食两用中药材中多环芳烃(polycyclic aromatic hydrocarbons,PAHs)的污染水平及其对人群健康的影响。方法查阅中药材中PAHs残留污染相关文献,搜集中药材受PAHs污染的数据,采用美国环保局(United States of America,Environmental Protection Agency,USA EPA)推荐的终生致癌风险(incremental lifetime cancer risk,ILCR)为度量指标,进行健康风险评价。结果药食两用中药材中PAHs残留的总含量范围为nd~5400.99μg/kg,均值为828.603μg/kg,中药材中PAHs平均浓度为:甘草>杜仲>玫瑰花>地黄>连翘>人参。健康风险评价表明不同年龄组摄入人参、连翘的致癌风险可以忽略(ILCR小于10^(-6)),摄入甘草、玫瑰花存在潜在的致癌风险(ILCR在10^(-6)~10^(-4)之间);不同人群的终生致癌风险顺序为:成年人>儿童>老年人>青少年;6种中药材受PAHs污染的程度不同,所引起的致癌风险为:甘草>玫瑰花>地黄>杜仲>连翘>人参。结论6种药食两用中药材中普遍存在PAHs污染,对人群健康有一定的危害,本研究利用终生致癌风险评价模型对药食两用的中药材PAHs污染情况进行预警,有助于以中药材为原料的药食两用食品的开发研究,同时为制定中药材中PAHs污染控制标准提供参考依据。
Objective To investigate the pollution levels of polycyclic aromatic hydrocarbons(PAHs)in 6 kinds of Chinese medicinal and edible materials of ginseng,liquorice,rehmannia glutinosa,eucommia ulmoides,forsythia suspensa and rose and their effects on people’s health.Methods Literature related to PAHs residue pollution in Chinese medicinal materials was consulted,and the data of PAHs pollution in Chinese medicinal materials were collected,the incremental lifetime cancer risk(ILCR)recommended by the(United States of America,Environmental Protection Agency(USA EPA)was used as the measurement index to conduct health risk assessment.Results The total content of PAHs residues in medicinal and edible Chinese medicinal materials ranged from nd to 5400.99μg/kg,with the average value of 828.603μg/kg.The average concentration of PAHs in Chinese medicinal materials was:Glycyrrhiza uralensis>eucommia ulmoides>rose>rehmannia glutinosa>forsythia suspense>ginseng.Health risk assessment showed that the carcinogenic risks of intake of ginseng and forsythia in different age groups were negligible(ILCR was less than 10^(-6)),and the intake of licorice and rose had potential carcinogenic risks(ILCR ranged from 10^(-6) to 10^(-4));the lifetime carcinogenic risk of different populations was in the order of adults>children>elderly>adolescents.The 6 kinds of Chinese medicinal materials were polluted to different extents by PAHs,and the carcinogenic risks caused by PAHs were liquorice>rose>rehmannia>glutinosa>eucommia ulmoides>forsythia suspensa>ginseng.Conclusion PAHs pollution is common in 6 kinds of medicinal and edible Chinese herbal medicines,which is harmful to people’s health to some extent.This study uses a lifetime carcinogenic risk assessment model to make an early warning of PAHs pollution in medicinal and edible Chinese herbal medicines,which is helpful to the development and research of medicinal and edible foods with Chinese herbal medicines as raw materials,and provides a reference for formulating PAHs pollution control standards in Chinese herbal medicines.
作者
曹德艳
赵思源
秦佳琪
王焱
周同宁
朱美霖
CAO De-Yan;ZHAO Si-Yuan;QIN Jia-Qi;WANG Yan;ZHOU Tong-Ning;ZHU Mei-Lin(School of Public Health and Management,Ningxia Medical University,Yinchuan 750004,China;Key Laboratory of Environmental Factors and Chronic Disease Control,Ningxia Medical University,Yinchuan 750004,China;College of Basic Medical Sciences,Ningxia Medical University,Yinchuan 750004,China)
出处
《食品安全质量检测学报》
CAS
北大核心
2022年第12期3899-3906,共8页
Journal of Food Safety and Quality
基金
国家自然科学基金项目(21966025、21667023)
教育部春晖计划项目(Z2016068)。
关键词
药食两用
中药材
多环芳烃
致癌风险评估
medicinal and edible
Chinese herbal medicine
polycyclic aromatic hydrocarbons
carcinogenic risk assessment
