摘要
目的研究糖化血红蛋白(HbA1c)、C肽(CP)与2型糖尿病肝功能异常之间的相关性。方法研究对象为该院2021年3—12月收治的60例2型糖尿病患者,根据HbA1c测量值不同将所有患者分为两组。以HbA1c≤9%的30例患者为A组,以HbA1c>9%的30例患者为B组,分析患者HbA1c、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、空腹C肽(FCP)、餐后2 hC肽(2 hCP)及丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(γ-GT)、总蛋白(TP)、总胆红素(TB)水平。结果B组FPG、2 hPG水平均高于A组,差异有统计学意义(P<0.05);B组FCP、2 hCP水平均低于A组,差异有统计学意义(P<0.05);A组8例患者肝功能指标异常,总异常率为26.67%,B组21例患者肝功能指标异常,总异常率为70.00%,B组肝功能总异常率高于A组,差异有统计学意义(P<0.05);B组AST、ALT、γ-GT水平均高于A组,差异有统计学意义(P<0.05),两组TB、TP水平差异无统计学意义(P>0.05);2型糖尿病患者肝功能异常与HbA1c水平、血糖水平为正相关,与CP水平为负相关(P<0.05)。结论2型糖尿病患者肝功能异常与HbA1c水平、血糖水平为正相关,与CP水平为负相关,有效控制血糖水平可降低肝功能异常发生率。
Objective To study the correlation between glycosylated hemoglobin(HbA1c),C-peptide(CP)and abnormal liver function in type 2 diabetes.Methods The research subjects were 60 patients with type 2 diabetes admitted to the hospital from March to December 2021.All patients were divided into two groups according to different HbA1c measurements.Take 30 patients with HbA1c≤9%as group A,and 30 patients with HbA1c>9%as group B,analyzed the patients'HbA1c,fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),fasting C-peptide(FCP),Postprandial 2 hC peptide(2 hCP)and alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyl transferase(γ-GT),total protein(TP),total Bilirubin(TB)levels.Results The levels of FPG and 2 hPG in group B were higher than those in group A,the difference was statistically significant(P<0.05);the levels of FCP and 2 hCP in group B were lower than those in group A,the difference was statistically significant(P<0.05);eight patients in group A had abnormal liver function indexes,and the total abnormal rate was 26.67%,in group B,21 patients had abnormal liver function indexes,and the total abnormal rate was 70.00%,the total abnormal rate of liver function in group B was higher than that in group A,the difference was statistically significant(P<0.05);the levels of AST,ALT andγ-GT in group B were higher than those in group A,the difference was statistically significant(P<0.05),and there was no statistically significant difference in the levels of TB and TP between the two groups(P>0.05);abnormal liver function in patients with type 2 diabetes was positively correlated with HbA1c level and blood glucose level,and negatively correlated with CP level(P<0.05).Conclusion Abnormal liver function in patients with type 2 diabetes is positively correlated with HbA1c level and blood glucose level,and negatively correlated with CP level.Effective control of blood glucose level can reduce the incidence of abnormal liver function.
作者
张思楠
ZHANG Sinan(Department of Laboratory Medicine,Beijing Huairou Hospital,Beijing,101400 China)
出处
《糖尿病新世界》
2022年第10期23-27,共5页
Diabetes New World Magazine
关键词
2型糖尿病
糖化血红蛋白
C肽
肝功能异常
Type 2 diabetes
Glycosylated hemoglobin
C-peptide
Abnormal liver function
