摘要
肉桂Cinnamomum cassia为樟科樟属植物,其干燥树皮、干燥嫩枝为中医临床常用药材,具有补火助阳、温里散寒的功效。近年来研究发现肉桂及其活性成分肉桂醛、反式肉桂醛、2′-羟基肉桂醛、2′-苯甲酰氧肉桂醛等具有良好的抗炎、解热镇痛、抗肿瘤、降糖等多种药理活性。基于中医药传统理论及现代医学研究,从调控细胞炎症分子、核因子-κB(nuclear factor-κB,NF-κB)、丝裂原激活的蛋白激酶(mitogenactivated protein kinase,MAPK)、酪氨酸激酶(Janus kinase,JAK)/信号传导与转录活化因子(signal transducer and activator of transcription,STAT)信号通路等方面,对肉桂及其活性成分治疗神经炎、关节炎、动脉粥样硬化等炎症性疾病作用机制的研究进展进行综述,为肉桂的深入研究及其在医药和保健品的应用开发提供参考。
Cinnamomum cassia is a plant of the genera Cinnamomum of Lauraceae.Its dried bark and twigs are commonly used in traditional Chinese medicine,which has the effect of supplementing fire to support yang and warming the interior to disperse cold.In recent years,it has been found that C.cassia and its active components cinnamaldehyde,trans-cinnamaldehyde,2′-hydroxycinnamaldehyde and 2′-benzoyloxycinnamaldehyde had excellent anti-inflammatory,antipyretic analgesic,anti-tumor,hypoglycemic and other pharmacological activities.Based on the theory of traditional Chinese medicine and modern medical research,research progress of C.cassia and its active components in treatment of inflammatory diseases such as neuritis,arthritis and atherosclerosis from the aspects of regulating cellular inflammatory molecules,NF-κB,MAPK,JAK/STAT signal pathway were reviewed in this paper,in order to provide a reference for further study of C.cassia and application development of medicine and dietary supplement.
作者
沈梦婷
白丹妮
王庆伟
平洋
赵宏
王丽红
苏瑾
SHEN Meng-ting;BAI Dan-ni;WANG Qing-wei;PING Yang;ZHAO Hong;WANG Li-hong;SU Jin(Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation,Department of Pharmacy,Jiamusi University,Jiamusi 154007,China)
出处
《中草药》
CAS
CSCD
北大核心
2022年第10期3218-3225,共8页
Chinese Traditional and Herbal Drugs
基金
黑龙江省北药与功能食品特色学科建设项目(2018-TSXK-02)
佳木斯大学优秀学科团队项目(JDXKTD-2019005)
黑龙江省卫生健康委立项课题(2018-482)。
关键词
肉桂
抗炎
神经炎症性疾病
关节炎
脓毒症
作用机制
Cinnamomum cassia Presl
anti-inflammatory
neuroinflammatory diseases
arthritis
sepsis
action mechanism
