摘要
目的探讨血清TGFBI蛋白、促胃液素-17(G-17)及幽门螺杆菌-IgG(HP-IgG)水平对早期胃癌患者内镜黏膜下剥离术(ESD)后复发的预测价值。方法选取2016年2月至2019年2月陕西省三二〇一医院(以下简称“我院”)行ESD治疗的255例早期胃癌患者,按是否复发将其分为复发组(20例)和未复发组(235例)。收集并比较两组临床资料及术前TGFBI蛋白、G-17、HP-IgG水平,分析行ESD的早期胃癌患者复发的影响因素。采用受试者操作特征曲线分析各指标及联合检测对早期胃癌ESD术后复发的预测价值。结果复发组浸润深度为黏膜下层占比及术前血清TGFBI、G-17、HP-IgG水平均高于未复发组,差异有统计学意义(P<0.05)。多因素分析结果显示,术前高血清TGFBI蛋白、G-17、HP-IgG水平及浸润深度为黏膜下层是早期胃癌患者ESD后复发的独立危险因素(OR>1,P<0.05)。术前血清TGFBI蛋白、G-17、HP-IgG联合检测预测早期胃癌患者ESD后复发的曲线下面积大于三者单独诊断(P<0.05)。结论联合检测ESD前血清TGFBI、G-17、HP-IgG水平对早期胃癌ESD术后复发具有较高的预测价值,值得临床进一步探究。
Objective To investigate the predictive value of serum TGFBI protein,gastrin-17(G-17),and Helicobacter pylori-IgG(HP-IgG)levels in patients with early gastric cancer after endoscopic submucosal dissection(ESD).Methods A total of 255 patients with early gastric cancer who received ESD treatment in Shaanxi Province 3201 Hospital(hereinafter referred to as“our hospital”)from February 2016 to February 2019 were selected,and they were divided into recurrence group(20 cases)and non-recurrence group(235 cases)according to wether recurrence.Clinical data and preoperative levels of TGFBI protein,G-17,and HP-IgG were collected and compared between the two groups to analyze the influencing factors of recurrence in early gastric cancer patients undergoing ESD.The predictive value of each index and combined detection for recurrence of early gastric cancer after ESD was analyzed by the receiver operation characteristic curve.Results The proportion of submucosal infiltration depth and the preoperative serum levels of TGFBI protein,G-17,and HP-IgG in the recurrence group were higher than those in the non-recurrence group,the differences were statistically significant(P<0.05).Multivariate analysis showed that preoperative high levels of serum TGFBI protein,G-17,HP-IgG,and submucosal infiltration depth were independent risk factors for recurrence after ESD in early stage gastric cancer patients(OR>1,P<0.05).Preoperative combined detection of serum TGFBI protein,G-17,and HP-IgG showed a greater area under the curve in predicting recurrence after ESD in patients with early gastric cancer than that of TGFBI protein,G-17,and HP-IgG alone(P<0.05).Conclusion The combined detection of serum levels of TGFBI,G-17,and HP-IgG before ESD have high predictive value for recurrence of early gastric cancer after ESD,and it is worthy for clinical investigation.
作者
潘春生
范志刚
PAN Chunsheng;FAN Zhigang(Department of Gastroenterology,Shaanxi Province 3201 Hospital,Shaanxi Province,Hanzhong 723000,China;Department of Oncology,Shaanxi Province 3201 Hospital,Shaanxi Province,Hanzhong 723000,China)
出处
《中国医药导报》
CAS
2022年第14期109-112,共4页
China Medical Herald
基金
陕西省科技计划项目(2021SF-044)。
