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脂代谢紊乱在肥胖相关骨性关节炎病程进展中作用的研究进展 被引量:2

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摘要 骨性关节炎已成为老年人致残的主要原因之一,约4%的老年人残疾是由骨性关节炎导致[1-2]。骨性关节炎是一种不可逆的慢性疾病,主要的两个病理特征为关节软骨损伤和软骨下骨硬化,其病理损伤累及整个关节,包括软骨退化、骨重塑、骨赘形成和滑膜炎症,导致关节疼痛、僵硬、丧失正常功能;滑膜炎症导致滑液分泌过多,关节囊肿胀,连接关节的肌肉受抑制并长期失用,最终导致肌肉萎缩和残疾[3]。
出处 《中国骨与关节损伤杂志》 2022年第4期439-442,共4页 Chinese Journal of Bone and Joint Injury
基金 国家自然科学基金项目(81801601) 上海市科技计划项目(20Y11911600)。
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