摘要
天然产品中药精油因其独特的生物学特性在医药、食品、化妆品等领域广受欢迎。然而中药精油这种亲脂性化合物挥发性强、稳定性差、刺激性强,需要运用各种制剂技术改善稳定性、减少刺激性并增加生物利用度。目前,多种制剂技术运用于中药精油包封过程,不同递释系统具有不同原理与特点进而形成了多种包封策略,并广泛应用于中药精油稳定性的改善。中药精油在医药领域应用广泛,临床研究、制药工业、医疗产品等方面不断创新发展。因此针对改善中药精油稳定性的各种递释系统进行总结,并对各类递释系统包封中药精油在医药领域中的应用加以综述,以期为中药精油稳定性改善及其在医药领域的安全、高效、广泛使用提供参考。
Essential oils from Chinese medicine are popular in the fields such as medicine,food,and cosmetics because of their unique biological characteristics.However,since essential oils are lipophilic compounds with high volatility,poor stability,and strong irritation,various preparation technologies need to be employed to improve stability,reduce irritation,and increase bioavailability.At present,a variety of preparation technologies have been applied to the encapsulation of essential oils.Various encapsulation strategies are formed because of different delivery systems featured with multiple principles and characteristics and are widely used to improve the stability of essential oils.Essential oils of Chinese medicine are widely used in the medical field,and they are under continuous innovation and development in clinical research,the pharmaceutical industry,medical products,etc.The present study summarized various delivery systems that could improve the stability of essential oils and reviewed the applications of essential oils encapsulated in the delivery systems in the medical field to provide re-ferences for the improvement of stability of essential oils and their safety,efficiency,and wide use in the medical field.
作者
吴意
万娜
刘阳
廖嘉宝
张雨恬
伍振峰
杨明
WU Yi;WAN Na;LIU Yang;LIAO Jia-bao;ZHANG Yu-tian;WU Zhen-feng;YANG Ming(Key Laboratory of Modem Preparation of Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China;State Key Laboratory of Innovation Drug and Efficient Energy-Saving Pharmaceutical Equipment,Jiangxi University of Chinese Medicine,Nanchang 330004,China;China Resources Sanjiu Medical&Pharmaceutical Co.,Ltd.,Shenzhen 518110,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第3期603-610,共8页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(82074026)
江西省重大科技研发专项(20194ABC28009)
省级大学生创新创业计划项目(S202110412005)
江西省重点研发计划项目(20192BBG70072)
江西省中医药管理局科技计划项目(2019A031)
江西省教育厅科学研究青年项目(GJJ180692)
江西中医药大学创新药物与高效节能降耗制药设备国家重点实验室开放基金项目(GZSYS202008)。
关键词
挥发油
稳定性改善
递释系统
制剂技术
医药领域
应用研究
essential oils
stability improvement
delivery system
preparation technology
medical field
application research
