摘要
牛奶蛋白过敏常见于婴幼儿,是由牛奶蛋白引起的异常免疫反应,发病机制可分为IgE或非IgE介导,亦或两者混合介导。目前我国已有多项牛奶蛋白过敏的专家共识,但这些共识均未对IgE和非IgE介导的牛奶蛋白过敏进行区分。鉴于两者在临床上有着明显不同,且婴儿时期非IgE介导的牛奶蛋白过敏更为常见,故中华预防医学会过敏病预防与控制专业委员会组织儿科消化、过敏/免疫、皮肤、营养和儿童保健专业专家,针对非IgE介导的牛奶蛋白过敏类型、临床特征、诊断和营养干预,参考国际指南并结合我国临床实践制定了本指南。本指南的建议更适合基层医师的理解和实践,涉及非IgE介导的牛奶蛋白过敏问题共7大类42条建议。
Cow′s milk protein allergy(CMPA)is one of the most common presentations of food allergy seen in early childhood.It is an abnormal immune response caused by cow′s milk protein.CMPA can be clinically subdivided into either immediate-onset IgE mediated or delayed onset non-IgE mediated,or both.At present,concerns regarding the early and timely diagnosis of CMPA have been high-lighted over the years and there are many expert consensus on CMPA in China,but these consensus did not distinguish IgE mediated or non-IgE mediated CMPA.In view of the obvious clinical differences between the two type of CMPA and non-IgE mediated CMPA is more common in infancy,experts focus on pediatric gastroenterology,allergy/immunology,dermatology,nutrition and child healthcare convened by the Allergy Prevention and Control Professional Committee of Chinese Preventive Medicine Association present this guideline to help practitioners in primary care settings to early recognize and make suitable management of non-IgE mediated CMPA in China.The guideline incorporates the cutting-edge international guidance and the actual situation of Chinese children describing in detail the types,clinical features,diagnosis and nutritional intervention of non-IgE mediated CMPA.There are 42 recommendations in 7 categories in total referring to the common questions related to non-IgE mediated CMPA.
作者
陈同辛
洪莉
王华
邵洁
杨凡
王莹
刘光辉
徐樨巍
盛晓阳
许春娣
Chen Tongxin;Hong Li;Wang Hua;Shao Jie;Yang Fan;Wang Ying;Liu Guanghui;Xu Xiwei;Sheng Xiao-yang;Xu Chundi(Department of Allergy/Immunology,Shanghai Children′s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine,National Children′s Medical Center(Shanghai),Shanghai 200127,China;Department of Nutrition,Shanghai Children′s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine,National Children′s Medical Center(Shanghai),Shanghai 200127,China;Department of Dermatology,Children′s Hospital Affiliated to Chongqing Medical University,Chongqing 400015,China;Department of Pediatrics,Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;Department of Child Health Care,West China Second Hospital,Sichuan University,Chengdu 610041,China;Department of Gastroenterology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200092,China;Department of Allergy,Central South Hospital of Wuhan University,Wuhan 430062,China;Department of Pediatrics,Beijing Tsinghua Changgung Hospital Affiliated Tsinghua University,Beijing 102218,China;Department of Child Health Care,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200092,China)
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2022年第4期241-250,共10页
Chinese Journal of Applied Clinical Pediatrics
关键词
牛奶蛋白过敏
指南
非IgE介导
婴儿
诊断
营养干预
Cow′s milk protein allergy
Guideline
Non-IgE mediated
Infant
Diagnosis
Nutritional intervention
