摘要
目的:探究首发与慢性精神分裂症患者P50感觉门控特征的差异。方法:招募门诊与住院的首发精神分裂症患者97例,慢性精神分裂症患者197例,正常对照253例。采用听觉配对刺激条件-测试范式对所有受试者进行P50指标测量。将S2波幅与S1波幅的比值作为主要结局指标。结果:首发精神分裂症组S1潜伏期、S2潜伏期均高于慢性精神分裂症组与正常对照组(均P<0.001)。首发精神分裂症组和正常对照组S1波幅与S2波幅比值低于慢性精神分裂症组[0.4(-0.4,1.7),0.4(-0.7,2.0)vs.0.6(-2.3,4.0),均P<0.05]。慢性精神分裂症组S1波幅与S2波幅差值小于首发精神分裂症组和正常对照组[1.2(-3.9,9.2)μV vs.1.7(-1.0,6.7)μV,1.9(-2.3,8.9)μV,均P<0.01]。结论:慢性精神分裂症患者P50感觉门控功能缺陷可能较首发患者严重,首发精神分裂症患者S1潜伏期、S2潜伏期延长可能为感觉门控功能的代偿表现。
Objective:To investigate the differences of auditory P50 sensory gating between first-episode and chronic schizophrenics.Methods:Totally 97 patients with first-episode schizophrenia,197 patients with chronic schizophrenia,and 253 normal controls were recruited.P50 measurements of paired-clicks conditioning-testing paradigm were used to evaluate the sensory gating for all the participants.The P50 ratio was regarded as the primary outcome measures.Results:The S1 latency and S2 latency were higher in patients with first-episode schizophrenia than in patients with chronic schizophrenia and normal controls(Ps<0.001).The P50 ratios were lower in patients with first-episode schizophrenia and normal controls than in patients with chronic schizophrenia[0.4(-0.4,1.7),0.4(-0.7,2.0)vs.0.6(-2.3,4.0),Ps<0.05].The absolute differences between S1 amplitude and S2 amplitude were smaller in patients with chronic schizophrenia than in patients with first-episode schizophrenia and normal controls[1.2(-3.9,9.2)μV vs.1.7(-1.0,6.7)μV,1.9(-2.3,8.9)μV,Ps<0.01].Conclusion:Compared with patients with first-episode schizophrenia,the deficits of P50 sensory gating may be severer in patients with chronic schizophrenia.The prolongation of S1 latency and S2 latency may be a compensatory mechanism of sensory gating in patients with first-episode schizophrenia.
作者
刘丹
范宏振
赵艳丽
陈楠
张进国
李东
王志仁
谭云龙
谭淑平
LIU Dan;FAN Hongzhen;ZHAO Yanli;CHEN Nan;ZHANG Jinguo;LI Dong;WANG Zhiren;TAN Yunlong;TAN Shuping(Peking University Huilongguan College of Clinical Medical School,Beijing Huilongguan Hospital,Beijing 100096,China)
出处
《中国心理卫生杂志》
CSCD
北大核心
2022年第4期282-286,共5页
Chinese Mental Health Journal
基金
国家自然科学基金面上项目(31671145)
北京市自然科学基金(7202072)
北京市医院管理中心“登峰”计划(DFL20192001)。
