摘要
目的:观察盐酸米诺环素软膏联合碘甘油治疗牙龈炎患者的效果。方法:回顾性分析2020年6月至2021年6月该院收治的80例牙龈炎患者的临床资料,按照治疗方法不同分为对照组和观察组各40例。对照组采用碘甘油治疗,观察组在对照组的基础上联合盐酸米诺环素软膏治疗,比较两组临床疗效,治疗前后炎性因子[肿瘤坏死因子(TNF)-α、白细胞介素(IL)-8]水平、牙周健康指数[牙龈指数(GI)、菌斑指数(PLI)、龈沟出血指数(SBI)]评分、治疗满意度及不良反应发生率。结果:观察组治疗总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(P<0.05);治疗后,观察组TNF-α、IL-8水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组GI、PLI、SBI评分均低于对照组,差异有统计学意义(P<0.05);观察组治疗满意度为92.50%,高于对照组的75.00%,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸米诺环素软膏联合碘甘油治疗牙龈炎患者,可提高临床疗效,降低炎性因子水平,改善牙周健康,提高患者满意度,且安全性较高,其效果优于单纯碘甘油治疗。
Objective:To observe effects of Minocycline hydrochloride ointment combined with Iodine glycerin on patients with gingivitis.Methods:The clinical data of 80 gingivitis patients admitted to this hospital from June 2020 to June 2021 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,each with 40 cases.The control group was treated with Iodine glycerin,while the observation group was treated with Minocycline hydrochloride ointment on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[tumor necrosis factor(TNF)-α,interleukin(IL)-8],the periodontal health index[gingival index(GI),plaque index(PLI),sulcus bleeding index(SBI)]score,the treatment satisfaction.and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 97.50%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TNF-αand IL-8 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the GI,PLI,and SBI scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The treatment satisfaction of the observation group was 92.50%,which was higher than 75.00%of the control group,and the difference was statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Minocycline hydrochloride ointment combined with Iodine glycerin in the treatment of the patients with gingivitis can improve the clinical efficacy,reduce the levels of inflammatory factors,improve the periodontal health,improve the patient satisfaction,and have high safety.Moreover,it is superior to single Iodine glycerin treatment.
作者
刘孙辉
LIU Sunhui(Department of Oral Medicine of Liudu Hospital of Minqing County,Fuzhou 350000 Fujian,China)
出处
《中国民康医学》
2022年第1期49-51,共3页
Medical Journal of Chinese People’s Health
关键词
牙龈炎
碘甘油
盐酸米诺环素软膏
牙周健康
炎性因子
Gingivitis
Iodine glycerol
Minocycline hydrochloride ointment
Periodontal health
Inflammatory factor
